A continuous-flow microbial microreactor using microbes immobilized into a microporous carrier by dielectrophoresis

Kano, Tomonori; Inaba, Tomomi; Gu, Yu; Miki, Norihisa

doi:10.1109/memsys.2012.6170293

Cited by 1 publication

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References 13 publications

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“…(5) It has been demonstrated that microscale cell separation or isolation can be realized by adopting different mechanisms, such as microchannels with specific geometric or structural designs, (6) and by manipulating microparticles using noninertial forces, such as acoustic, magnet-based, (7) and dielectrophoresis (DEP) forces. (8,9) In addition, a number of micropumps with gas bubbles have recently been applied to microfluidic devices and employed to manipulate microparticles using noncontact forces, leading to numerous successful microchip designs for particle and cell separation. For example, a patch-clamp (PC) microchip with cell sorting and positioning functions has been reported and shows promise for use in an automated PC microsystem.…”

Section: Introductionmentioning

confidence: 99%

Single Microparticle Separation by Thermal Bubble Actuation in Microfluidic Chips

2014

Sensors and Materials

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Cell and microparticle separation in microfluidic systems, which is typically achieved by applying forces to the targets to guide them along different paths, has recently gained significant attention for the preparation of samples in biological and chemical studies. Therefore, we propose a new microfluidic chip with a resistive silicon-based microheater, where noncontact force is applied by thermal bubble actuation for microparticle separation. The static and dynamic electrothermal coupling characteristics of the resistive microheater and the flow behaviors of fluid in the microchannel were evaluated by finite-element analysis and using the commercial simmulation software COMSOL, respectively, to provide an applicable design. The feasibility of a thermal bubblepumping fluid to manipulate a microbead of 20 μm diameter has also been verified by experiments. It is expected that the proposed microfluidic chip can be applied to the separation of cells, such as live cells in amniotic fluid.

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Section: Introductionmentioning

confidence: 99%

Single Microparticle Separation by Thermal Bubble Actuation in Microfluidic Chips

2014

Sensors and Materials

View full text Add to dashboard Cite

show abstract

A continuous-flow microbial microreactor using microbes immobilized into a microporous carrier by dielectrophoresis

Cited by 1 publication

References 13 publications

Single Microparticle Separation by Thermal Bubble Actuation in Microfluidic Chips

Single Microparticle Separation by Thermal Bubble Actuation in Microfluidic Chips

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