2013
DOI: 10.1159/000350366
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A Contraction Assay System Using Primary Cultured Mouse Bronchial Smooth Muscle Cells

Abstract: Background: Contraction of bronchial smooth muscle is the main mechanism of asthmatic responses. Inflammatory cells such as eosinophils and mast cells produce chemical mediators that induce smooth muscle contraction. To investigate the mechanisms of IgE-independent asthmatic response in murine asthma models, a novel in vitro assay system using primary cultured mouse bronchial smooth muscle cells (BSMC) was explored. Method: Trachea and bronchi were taken from young mice and underwent primary culture. BSMC were… Show more

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Cited by 2 publications
(1 citation statement)
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“…CysLTs are thought to be essential for the pathogenesis of acute and chronic asthma because they are the most potent bronchoconstrictors in humans [48,81]; indeed, they are much more potent than histamine [82]. CysLTs are detected in blood, BAL fluid, and urine samples from asthmatic patients after bronchospasm.…”
Section: Lts and Allergic Diseasesmentioning
confidence: 99%
“…CysLTs are thought to be essential for the pathogenesis of acute and chronic asthma because they are the most potent bronchoconstrictors in humans [48,81]; indeed, they are much more potent than histamine [82]. CysLTs are detected in blood, BAL fluid, and urine samples from asthmatic patients after bronchospasm.…”
Section: Lts and Allergic Diseasesmentioning
confidence: 99%