A Contrast‐Enhanced Ultrasonographic Study About the Impact of Long‐term Exercise Training on Mammary Tumor Vascularization

Faustino-Rocha, Ana I.; Gama, Adelina; Oliveira, Paula A.; Vanderperren, Katrien; Saunders, Jimmy; Pires, Maria dos Anjos; Ferreira, Rita; Ginja, Mário

doi:10.1002/jum.14287

Cited by 6 publications

(5 citation statements)

References 36 publications

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“…CEUS has been extensively used to image angiogenesis [18], [30], specifically the effect of physical exercise [33], [34], as well as characterizing tumor growth [30]. Our results (cf., Figure 3) for tissue perfusion are consistent with findings previously obtained by Faustino-Rocha et al [30] that exercise has no effect on perfusion as there were no differences between the FVB/NJ and SV40 Tag mice nor their subgroups ( P > .2). There was a high degree of variability in these perfusion measurements, especially within the SV40 Tag mice.…”

Section: Discussionsupporting

confidence: 52%

“…Understanding the underlying mechanism by which DCIS progresses is key to minimizing overtreatment. Tissue oxygenation and perfusion are two markers that have been used to monitor and detect angiogenesis [18], [30], but to date have not been used to predict DCIS formation and progression. Additionally, studies have found that exercise helps reduce the risk of breast cancer occurrence, as well as reducing the risk of death post-diagnosis [1], [10], [28].…”

Section: Discussionmentioning

confidence: 99%

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Monitoring Progression of Ductal Carcinoma In Situ Using Photoacoustics and Contrast-Enhanced Ultrasound

Margolis

Wessner

Stanczak

et al. 2019

Translational Oncology

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Breast cancer is the leading form of cancer in women, accounting for approximately 41,400 deaths in 2018. While a variety of risk factors have been identified, physical exercise has been linked to reducing both the risk and aggressiveness of breast cancer. Within breast cancer, ductal carcinoma in situ (DCIS) is a common finding. However, less than 25% of DCIS tumors actually progress into invasive breast cancer, resulting in overtreatment. This overtreatment is due to a lack of predictive precursors to assess aggressiveness and development of DCIS. We hypothesize that tissue oxygenation and perfusion measured by photoacoustic and contrast-enhanced ultrasound imaging, respectively, can predict DCIS aggressiveness. To test this, 20 FVB/NJ and 20 SV40Tag mice that genetically develop DCIS-like breast cancers were divided evenly into exercise and control groups and imaged over the course of 6 weeks. Tissue oxygenation was a predictive precursor to invasive breast cancer for FVB/NJ mice ( P = 0.015) in the early stages of tumor development. Meanwhile, perfusion results were inconclusive ( P > 0.2) as a marker for disease progression. Moreover, voluntary physical exercise resulted in lower weekly tumor growth and significantly improved median survival ( P = 0.014).

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Monitoring Progression of Ductal Carcinoma In Situ Using Photoacoustics and Contrast-Enhanced Ultrasound

Margolis

Wessner

Stanczak

et al. 2019

Translational Oncology

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“…There are only two studies that have used this technology in animals, both evaluating chemically induced mammary tumours. These studies have reported that B-Flow is more sensitive than power colour Doppler in detecting tumour vessels [ 112 , 113 ].…”

Section: B-flowmentioning

confidence: 99%

Ultrasound-Based Technologies for the Evaluation of Testicles in the Dog: Keystones and Breakthroughs

Bracco,

Gloria,

Contri

2023

Veterinary Sciences

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Ultrasonography is a valuable diagnostic tool extensively used in the andrology of human and domestic animals, including dogs. This review aims to provide an overview of various technologies based on ultrasound, from the basic B-Mode ultrasonography to the more recent advancements, such as contrast-enhanced ultrasonography (CEUS) and ultrasound elastography (UEl), all of which are utilized in the evaluation of canine testicles. The review outlines the principles behind each of these technologies and discusses their application in assessing normal and abnormal testicular conditions. B-mode canine testicular ultrasonography primarily focuses on detecting focal lesions but has limitations in terms of objectivity. Other technologies, including Doppler ultrasonography, B-Flow, and CEUS, allow for the characterization of vascular patterns, which could be further measured using specific applications like spectral Doppler or quantitative CEUS. Additionally, ultrasound elastography enables the assessment of parenchyma stiffness both qualitatively and quantitatively. These ultrasound-based technologies play a crucial role in andrology by providing valuable information for evaluating testicular function and integrity, aiding in the identification of pathological conditions that may impact the health and quality of life of male dogs.

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“…In addition, contrast-enhanced MRI is contraindicated in certain patients, including those with pacemakers, renal impairment and others. With the advent of US contrast agents, several clinical studies have reported promising results using contrast-enhanced ultrasound (CEUS) in the breast cancer diagnosis 8–10. CEUS can identify slow and low-volume blood flow inside tumors from 20 to 39 μm in diameter;6 US contrast agents remain solely intravascular, enabling direct evaluation of the vasculature; however, CEUS is an imaging modality that requires an interventional procedure, injection of a contrast medium.…”

Section: Introductionmentioning

confidence: 99%

<p>Vascular index measured by smart 3-D superb microvascular imaging can help to differentiate malignant and benign breast lesion</p>

Zhang

et al. 2019

CMAR

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Purpose: The purpose of our study was to prospectively evaluate the diagnostic performance of the vascular index (VI, defined as the ratio of Doppler signal pixels to pixels in the total lesion) measured via Smart 3-D superb microvascular imaging (SMI) for breast lesions. Patients and methods: Two hundred and thirty-two consecutive patients with 236 breast lesions referred for biopsy at Peking Union Medical College Hospital were enrolled in the study from December 2016 to November 2017. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of VI were calculated with histopathologic results as the reference standard. Results: Of the 236 breast lesions, 121 were malignant and 115 were benign. The mean VI was significantly higher in malignant lesions (9.7±8.2) than that in benign ones (3.4±3.3) ( P <0.0001). Sensitivity, specificity, PPV, NPV and accuracy of VI (4.0 as the threshold) were respectively: 76.0%, 66.1%, 70.2%, 72.4% and 71.2% ( P <0.05). Conclusion: Smart three-dimensional (3-D) SMI is a noninvasive tool using two-dimensional (2-D) scanning to generate 3-D vascular architecture with a high-resolution image of micro-vessels. This can be used as a qualitative guide to identify the optimal 2-D SMI plane with the most abundant vasculature to guide VI quantitative measurements of breast lesions. Smart 3-D SMI may potentially serve as a noninvasive tool to accurately characterize benign versus malignant breast lesions.

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A Contrast‐Enhanced Ultrasonographic Study About the Impact of Long‐term Exercise Training on Mammary Tumor Vascularization

Abstract: The contrast-enhanced ultrasonographic study did not detect differences in mammary tumor vascularization between MNU sedentary and MNU exercised groups previously detected by power Doppler imaging, B-flow imaging, and immunohistochemistry.

Cited by 6 publications

References 36 publications

Monitoring Progression of Ductal Carcinoma In Situ Using Photoacoustics and Contrast-Enhanced Ultrasound

Monitoring Progression of Ductal Carcinoma In Situ Using Photoacoustics and Contrast-Enhanced Ultrasound

Ultrasound-Based Technologies for the Evaluation of Testicles in the Dog: Keystones and Breakthroughs

<p>Vascular index measured by smart 3-D superb microvascular imaging can help to differentiate malignant and benign breast lesion</p>

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