Within continental lithosphere, widespread seismic evidence suggests a sharp discontinuous downward decrease in seismic velocity at 60–160 km depth. This midlithospheric discontinuity (MLD) may be due to anisotropy, melt, hydration, and/or mantle metasomatism. We survey global seismologic observations of the MLD, including observed depths, velocity contrasts, gradients, and locales across multiple seismic techniques. The MLD is primarily found in regions of thick continental lithosphere and is a decrease in seismic shear velocity (2–7% over 10–20 km) at 60–160 km depth, the majority of observations clustering at 80–100 km. Of xenoliths in online databases, 25% of amphibole‐bearing xenoliths, 90% of phlogopite‐bearing xenoliths, and none of carbonate‐bearing xenoliths were formed at pressures associated with these depth (2–5 GPa). We used Perple_X modeling to evaluate the elastic moduli and densities of multiple petrologies to test if the MLD is a layer of crystallized melt. The fractional addition of 5–10% phlogopite, 10–15% carbonate, or 45–100% pyroxenite produce a 2–7% velocity decrease. We postulate this layer of crystallized melt would originate at active margins of continents and crystallize in place as the lithosphere cools. The concentration of mildly incompatible elements (Y, Ho, Er, Yb, and Lu) in xenoliths near the MLD is consistent with higher degrees of melting. Thus, we postulate that the MLD is the seismological signature of a chemical interface related to the paleointersection of a volatile‐rich solidus and progressively cooling lithosphere. Furthermore, the MLD may represent a remnant chemical tracer of the lithosphere‐asthenosphere boundary (LAB) from when the lithosphere was active and young.