This paper has the purpose to investigate HVDC insulation design considering real operating conditions, when DC steady-state is affected by frequent voltage transients or load variations that may be present during all life. Electrical field distribution in insulation, and in insulation defects, may change significantly from DC steady-state when voltage and load vary with time, which can cause partial discharge activity often not been properly accounted for at the design stage. The Part I of this paper is dedicated to prove, through experiments, models and simulations, that electrical and thermal transients may incept partial discharges in defective insulations during cable energization, voltage polarity inversion at a constant nominal load, as well as during load variations at a constant nominal voltage. This can cause accelerated aging and premature breakdown even if the insulation system is designed properly to withstand DC electrothermal stress, without partial discharges in steady state, for all life, as it will be shown in Part II. Focus is on cables, but the approach described here is general for any DC insulation system. INDEX TERMS Cable insulation, DC, voltage and load transients, design methodology, finite element analysis, partial discharges. Hadi Naderiallaf was born in Mashhad, Iran, on April 16th, 1986. He received the M.Sc. degree in electrical engineering in 2012 from the Leibniz Universität Hannover, Germany. He did his master thesis at the Schering Institute of High Voltage Techniques and Engineering in the Leibniz Universität Hannover. He has working experience for five years as a transformer fluid specialist. From November 2017, he has been a PhD student in the University of Bologna in Italy working on the EU project GRIDABLE. His main research interests are liquid and nanostructured solid electrical insulating materials, HVDC cables design, space charge measurement and analysis, AC and DC partial discharge detection and modelling, insulation systems for electrical machines, condition monitoring techniques, HV transformer asset management, DGA and transformer oil reclamation. Paolo Seri (M'17) was born in Macerata, Italy, on June 4th 1986. He received the M.Sc. degree in energy engineering in 2012 and PhD in electrical engineering in 2016, both from the University of Bologna. From 2017 he is part of the Laboratory of Innovative Materials for Electrical Systems (LIMES) of the University of Bologna as a research fellow, currently working on the topics of HVDC cables design, partial discharge detection and modelling, and characterization of dielectric materials. He is also