A contribution to the understanding of the formation of calcium phosphates

Christoffersen, J.; Christoffersen, Margaret R.; Kibalczyc, W.; Andersen, F. Allan

doi:10.1016/0022-0248(89)90102-4

Cited by 170 publications

(126 citation statements)

References 24 publications

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“…1c) with dimensions of 150-200 nm. In agreement with previous reports 14,[23][24][25] , these nodules condensed further, transforming into spheres that coagulated and subsequently precipitated after 15-20 min (Fig. 1d).…”

Section: Resultssupporting

confidence: 93%

“…LDSAED from plates aged for 1 month revealed a peak at d ¼ 0.28 nm corresponding to the (211)/(112) planes of AP (Fig. 3a), implicating that, as in previous reports 23,24,[28][29][30][31] , the OCP-like structure acted as a precursor for AP. These structural developments were supported by in situ Fourier transform infrared spectroscopy (FTIR, Fig.…”

Section: Resultssupporting

confidence: 82%

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Ion-association complexes unite classical and non-classical theories for the biomimetic nucleation of calcium phosphate

et al. 2013

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Despite its importance in many industrial, geological and biological processes, the mechanism of crystallization from supersaturated solutions remains a matter of debate. Recent discoveries show that in many solution systems nanometre-sized structural units are already present before nucleation. Still little is known about the structure and role of these so-called pre-nucleation clusters. Here we present a combination of in situ investigations, which show that for the crystallization of calcium phosphate these nanometre-sized units are in fact calcium triphosphate complexes. Under conditions in which apatite forms from an amorphous calcium phosphate precursor, these complexes aggregate and take up an extra calcium ion to form amorphous calcium phosphate, which is a fractal of Ca 2 (HPO 4 ) 3 2 À clusters. The calcium triphosphate complex also forms the basis of the crystal structure of octacalcium phosphate and apatite. Finally, we demonstrate how the existence of these complexes lowers the energy barrier to nucleation and unites classical and non-classical nucleation theories.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 82%

Ion-association complexes unite classical and non-classical theories for the biomimetic nucleation of calcium phosphate

et al. 2013

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“…An average Ca/P ratio of 1.64 Ϯ 0.14 was measured for crystalline mineral particles, whereas an average ratio of 1.34 Ϯ 0.17 was obtained for the amorphous particles. Thus, the bone crystalline mineral phases are similar to stoichiometric crystalline carbonated hydroxyapatite (with a theoretical value of 1.67), and the amorphous phases are similar to synthetic ACP, reported to have ratios of Ϸ1.35 (21). The wide range of the calcium-to-phosphate ratios measured here correlates well with the different degrees of crystallinities observed in the diffraction patterns (Fig.…”

Section: Resultssupporting

confidence: 78%

“…They are, however, common in amorphous materials (21). To investigate the nature of these spheres, mineral particles freshly extracted from the distal parts of an elongating caudal fin were deposited on a marked TEM grid.…”

Section: Resultsmentioning

confidence: 99%

“…In vitro, at neutral pH and moderate supersaturation, amorphous calcium phosphate (ACP) is often the first-formed deposit. Under these conditions, ACP transforms into octacalcium phosphate (OCP), which in turn transforms into the thermodynamically more stable hydroxyapatite (21). Recently, collagen mineralization via a transient amorphous calcium phosphate phase was shown in vitro to produce aligned intrafibrillar carbonated apatite crystals (15).…”

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confidence: 99%

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Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase

Mahamid

Sharir

Addadi

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

505

449

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A fundamental question in biomineralization is the nature of the first-formed mineral phase. In vertebrate bone formation, this issue has been the subject of a long-standing controversy. We address this key issue using the continuously growing fin bony rays of the Tuebingen long-fin zebrafish as a model for bone mineralization. Employing high-resolution scanning and transmission electron microscopy imaging, electron diffraction, and elemental analysis, we demonstrate the presence of an abundant amorphous calcium phosphate phase in the newly formed fin bones. The extracted amorphous mineral particles crystallize with time, and mineral crystallinity increases during bone maturation. Based on these findings, we propose that this amorphous calcium phosphate phase may be a precursor phase that later transforms into the mature crystalline mineral.biomineralization ͉ fish fin

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Two-dimensional vibrational correlation spectroscopy ofin vitro hydroxyapatite maturation

et al. 2000

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A contribution to the understanding of the formation of calcium phosphates

Cited by 170 publications

References 24 publications

Ion-association complexes unite classical and non-classical theories for the biomimetic nucleation of calcium phosphate

Ion-association complexes unite classical and non-classical theories for the biomimetic nucleation of calcium phosphate

Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase

Two-dimensional vibrational correlation spectroscopy ofin vitro hydroxyapatite maturation

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