A controlled assessment of the in vitro fertilization performance of British women of Indian origin compared with white women

Mahmud, Ghazala; Bernal, Andrés López; Yudkin, Pat; Ledger, William; Barlow, David H.

doi:10.1016/s0015-0282(16)57663-8

Cited by 28 publications

(29 citation statements)

References 7 publications

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“…[1011132034] We believe that it reflects the occurrence of POR earlier in women studied, as has been documented previously in certain ethnicities. [3] This study did not show any improvement in cycle parameters such as duration of treatment or dose of gonadotropins, as has been documented previously and only a nonsignificant reduction in cancellation rate. [1020] Unlike previous reports, the changes noted in peak E2 levels were only modest.…”

Section: Discussionsupporting

confidence: 73%

“…[27] POR due to either advanced age or other underlying causes affect the outcome adversely[428293031] and this appears to occur at a younger age in women of Indian ethnicity compared to Caucasian women. [3] With the increasing burden of POR, various adjuvant therapies are in use in an attempt to improve the outcome even though such a practice has been questioned in the light of very limited evidence available. [32]…”

Section: Discussionmentioning

confidence: 99%

“…[12] Even though the true incidence of POR in various ethnicities is unknown, it is believed that the magnitude varies between women of different ethnicities. [3] The cause of this remains unexplained in the large majority, even though genital tuberculosis may be an important aetiological factor. [4] In addition to the reduced success rate, emotional and financial burden associated with this diagnosis are well-understood.…”

Section: Introductionmentioning

confidence: 99%

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Impact of dehydroepiandrosterone on clinical outcome in poor responders: A pilot study in women undergoing in vitro fertilization, using bologna criteria

Jirge¹,

Chougule²,

Gavali³

et al. 2014

J Hum Reprod Sci

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OBJECTIVE:To evaluate the role of dehydroepiandrosterone (DHEA) supplementation in women with poor ovarian response (POR) undergoing in vitro fertilization (IVF).DESIGN:Prospective case-control study.SETTING:Private tertiary fertility clinic.MATERIALS AND METHODS:31 infertile women with POR diagnosed as per the Bologna criteria.INTERVENTIONS:DHEA supplementation for 2 months and a subsequent IVF cycle, after two previous IVF cycles with POR.MAIN OUTCOME MEASURE(S):Dose and duration of gonadotropin therapy, oocyte yield, embryo number and quality, pregnancy and live birth rate.RESULTS:No difference was seen in gonadotropin requirement before and after DHEA supplementation. There was a significant increase in total and metaphase II oocytes (5.9 ± 0.68 vs. 2.73 ± 0.24; 4.45 ± 0.47 vs. 2.09 ± 0.26), fertilization (3.65 ± 0.49 vs. 2.00 ± 0.27), Grade I embryos (1.52 ± 0.25 vs. 0.55 ± 0.18), pregnancy rate (30% vs. 9.1%) and live birth rate (25% vs 0%) in those who completed the cycle, following DHEA supplementation.CONCLUSIONS:Dehydroepiandrosterone supplementation results in an improvement in oocyte yield, embryo quality, and live birth rate in a group of women with POR having undergone at least two previous failures due to POR.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of dehydroepiandrosterone on clinical outcome in poor responders: A pilot study in women undergoing in vitro fertilization, using bologna criteria

Jirge¹,

Chougule²,

Gavali³

et al. 2014

J Hum Reprod Sci

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“…Although there is no universally accepted definition, these patients represent about 10% of the population undergoing assisted reproduction treatment [2].…”

mentioning

confidence: 99%

“…Serafini et al [1] defined poor responders as those who produced less than 3 follicles despite badequateQ ovarian stimulation. Although there is no universally accepted definition, these patients represent about 10% of the population undergoing assisted reproduction treatment [2].…”

mentioning

confidence: 99%

Prolonged ovarian hyperstimulation for poor responders in in‐vitro fertilization treatment cycles

Ahmad¹,

Lewis‐Jones²,

Gazvani³

2006

Intl J Gynecology & Obste

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The management of poor responders to controlled ovarian hyperstimulation (COH) in an in-vitro fertilization setting presents clinicians with several dilemmas. Serafini et al.[1] defined poor responders as those who produced less than 3 follicles despite badequateQ ovarian stimulation. Although there is no universally accepted definition, these patients represent about 10% of the population undergoing assisted reproduction treatment [2].Poor responders have been reported to experience reduced pregnancy rates when compared with normal responders [3]. Despite various stimulation protocols, the ideal number of days of COH still remains unknown.A retrospective study was conducted to evaluate the impact of prolonged ovarian stimulation on treatment outcome in poor responders. Over a 12-month period, 77 cycles of poor responders were identified. The criteria for poor response used for the study was ultrasound evidence of less than 3 follicles of size larger than 15 mm size on day 9/10 of stimulation. Ninety-two cycles were undertaken over the same period, where stimulation was restricted to 9/10 days and showed more than 3 follicles larger than 15 mm; these women were classified as normal responders and formed the control group. The main outcome measure was clinical pregnancy rate.Successful implantation was determined by positive urinary beta hCG, and a clinical pregnancy by the presence of fetal heart beat on vaginal scan 4-6 weeks after embryo transfer of the 731 consecutive cycles in the study period, 77 (10.5%) were identified in which COH had been carried out for a maximum of 12 days. 92 patients were normal 0020-7292/$ -see front matter D

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Infertility Status and Infertility Treatment: Racial and Ethnic Disparities

Guendelman

Stachel²

2010

Reducing Racial/Ethnic Disparities in Reproductive and Perinatal Outcomes

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A controlled assessment of the in vitro fertilization performance of British women of Indian origin compared with white women

Cited by 28 publications

References 7 publications

Impact of dehydroepiandrosterone on clinical outcome in poor responders: A pilot study in women undergoing in vitro fertilization, using bologna criteria

Impact of dehydroepiandrosterone on clinical outcome in poor responders: A pilot study in women undergoing in vitro fertilization, using bologna criteria

Prolonged ovarian hyperstimulation for poor responders in in‐vitro fertilization treatment cycles

Infertility Status and Infertility Treatment: Racial and Ethnic Disparities

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