A Controlled Comparison of Imipramine and Electroplexy

Robin, A. A.; Harris, J. A.

doi:10.1192/bjp.108.453.217

Cited by 62 publications

(19 citation statements)

References 10 publications

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“…These experiences set the stage for the BCT and antidepressant drug comparisons that are the basis of our present practice. ECT was found more effective or equal to thymoleptics (19,27,35,36,39,50,52,55,58,62,68) (Table 3). BCT was also more effective than monoamine oxidase inhibitors (MAOI) (39,47,48,62,65), or phenelzine and amitriptyline combined (22).…”

Section: Fluctuating Course Tearfulnessmentioning

confidence: 90%

Convulsive and Drug Therapies of Depression

Fink¹

1981

Annu. Rev. Med.

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Section: Fluctuating Course Tearfulnessmentioning

confidence: 90%

Convulsive and Drug Therapies of Depression

Fink¹

1981

Annu. Rev. Med.

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“…E.C.T. is probably the treatment of choice for moderate to severe depressions (Robin and Harris, 1962;Greenblatt et al, 1964;Lockett and Milner, 1965;Medical Research Council Psychiatric Committee Report, 1965). In recent years there has been an appreciation of the clinical manifestations of cricoarytenoid -arthritis and the frequency of its occurrence in rheumatoid disease (Montgomery, 1963;Wolman, Darke, and Young, 1965).…”

Section: Casementioning

confidence: 99%

Adynamic Ileus and Nortriptyline

Milner¹,

Hills²

1966

BMJ

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SIR,-We would like to comment briefly on Dr. J. M. Sowa's letter (2 April, p. 858) dealing with the immunosuppressive therapy of systemic lupus erythematosus (S.L.E.).We published the results we obtained with 2,3,5 -tris -ethylenimino -p -benzoquinone (triaziquone) in three cases of S.L.E., and since then we treated another patient with the same cytostatic agent.Since in these cases the steroid therapy gave little advantage or serious side-effects, we tried the triaziquone therapy, which gave very good results: the sedimentation rate promptly fell to almost normal values, both the L.E. cell test and the L.E. factor test became negative, the electrophoretic pattern and the renal clearances and the urine analysis showed a marked improvement, the latter leaving only a residual slight albuminuria. The longest remission period was of two and a half years, and up to now a second cycle of treatment has not been necessary. The side-effects were negligible and promptly subsided on discontinuing the therapy.In our opinion the newer immunosuppressive drugs are of definite value in the treatment of S.L.E., provided that the following criteria are observed:(1) Their use should be limited to cases which either do not respond to doses of 50-60 mg. of prednisone daily or show some side-effect. In our experience doses of 100-120 mg. of prednisone daily almost always produce serious side-effects.(2) The dosage should be kept as low as possible (for triaziquone 2-3 mg. in all), and the therapy should be discontinued when the clinical condition and the laboratory tests show a marked improvement.(3) It is advisable that the cytostatic agents should be administered together with as little as 5-10 mg. of prednisone daily.Though more data, obtained possibly with a controlled study, are required, we strongly suggest the treatment of patients with S.L.E. who do not promptly respond to steroid therapy with triaziquone or other immunosuppressive drugs.-We are, etc., FRANCO PACINI. ANTONIO MORETTINI.

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“…However, no one would suggest that as treatment for all depression, they are as effective as electroconvulsive therapy. 22 The iminodibenzyl preparations at present in use are derived from cycloheptadiene and azepine preparations. Cycloheptadiene is the basic ring structure of amitriptyline (Elavil) and nortriptyline (Aventyl).…”

Section: The Iminodibenzyl Agentsmentioning

confidence: 99%

Antidepressant drug therapy

Friend¹

1965

Clin Pharma and Therapeutics

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Medicine had very little to offer in the treatment of the mentally depressed patient until the advent of shock therapy and the first monamine oxidase inhibitor, iproniazid. Unquestionably, the rather striking effects of iproniazid on mentally depressed individuals did much to stimulate interest in chemotherapy for this widespread and severely incapacitating mental condition. A large proportion of those with depression have a spontaneous remission 3 to 6 weeks after onset, but the situation may be serious during that period. In some, the condition does not undergo remission, grows steadily worse, and in others, leads to suicide. Continuous severe depression bringing about severe withdrawal of the individual from the main stream of life, ultimately leads to untreatable deteriorated states. It is, therefore, important that diagnosis be made as early as possible and treatment initiated promptly. Fortunately, drug therapy is now available which has much to offer these patients and even in the hands of the non psychiatrically oriented physician, oftentimes affords such relief as to return a patient to a much more useful and satisfactory existence.

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A Controlled Comparison of Imipramine and Electroplexy

Cited by 62 publications

References 10 publications

Convulsive and Drug Therapies of Depression

Convulsive and Drug Therapies of Depression

Adynamic Ileus and Nortriptyline

Antidepressant drug therapy

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