A Controlled Comparison of Metiapine and Chlorpromazine in Chronic Schizophrenia

Chlorpromazine versus metiapine for schizophrenia

“…Two included studies were parallel (Kramer 1975;Steinbook 1975) and one was cross-over (Simpson 1973). All studies were randomised.…”

“…Study size was small ranging from 11 (Simpson 1973) to 90 ( Kramer 1975) participants per trial. A total of 161 participants were randomised.…”

“…The doses of metiapine in included studies ranged from 25 mg/day to 600 mg/day (mean dose 219 mg/day) (Kramer 1975); 75 mg/ day to 450 mg/day (mean dose 287 mg/day) (Steinbook 1975); and 100 mg/day to 600 mg/day (mean dose was not provided) (Simpson 1973).…”

“…All studies described the methods used for random sequence generation and rated as low risk. One study reported that participants were randomly assigned in blocks of six (Kramer 1975), and one study reported that participants were randomised using table of random numbers (Simpson 1973). Steinbook 1975 reported participants were randomly allocated to groups and the resulting groups did not differ significantly with respect to age, race, education or number of previous hospitalisations.…”

“…All studies reported as double-blind studies and rated as low risk for performance bias. However, only one study stated that in addition to blinding of treatment, the physicians or nurses conducting outcome assessment were also blind (Simpson 1973). Kramer 1975 andSteinbook 1975 did not provide this information and we rated these two studies as unclear risk for detection bias.…”