1988
DOI: 10.1001/archpsyc.1988.01800280038006
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A Controlled Family Study of Chronic Psychoses

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Cited by 329 publications
(71 citation statements)
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“…The emergence of overlaps for bipolar disorder and schizophrenia loci on 13q32 (23) and 18p11. 2 (30) is consistent with family studies that showed an increased risk among first degree relatives of schizophrenia probands for schizoaffective and recurrent unipolar disorders (31,32).…”
Section: Resultssupporting
confidence: 86%
“…The emergence of overlaps for bipolar disorder and schizophrenia loci on 13q32 (23) and 18p11. 2 (30) is consistent with family studies that showed an increased risk among first degree relatives of schizophrenia probands for schizoaffective and recurrent unipolar disorders (31,32).…”
Section: Resultssupporting
confidence: 86%
“…The question of whether schizoaffective disorder constitutes a separate disorder or shares a common etiology with either schizophrenia or bipolar disorder remains highly controversial. [16][17][18] While the present study does not support an involvement of hyperprolinemia in DSM IIIR schizophrenia, we cannot exclude at the present stage that this risk factor might be shared between schizoaffective disorder and bipolar disorder. Finally, it should be stressed that the evidence for an association is modest (P ¼ 0.02) and has not been corrected for multiple testing (three clinical phenotypes).…”
Section: Discussioncontrasting
confidence: 84%
“…Early enthusiasm (Egeland et al, 1987;Gershon et al, 1988) was quickly curtailed (Kelsoe et al, 1989), as it became apparent that the strategy successfully employed to identify genes for many singlegene disorders would not be nearly as useful for identifying most of the genetic variation contributing to complex phenotypes. Many strategies have been adopted in gene identification efforts to deal with the complexities introduced by studying disorders that are believed to have multifactorial, polygenic origins, rather than simple Mendelian patterns of inheritance.…”
Section: Introductionmentioning
confidence: 99%