A controlled positron emission tomography study of obsessive and neutral auditory stimulation in obsessive-compulsive disorder with checking rituals

Cottraux, Jean; Gérard, Daniel; Cinotti, L.; Froment, J; Deiber, Marie-Pierre; Bars, Didier Le; Galy, G.; Millet, Philippe; Labbé, Claire; Lávenne, F.; Bouvard, Martine; Mauguı̀ere, François

doi:10.1016/0165-1781(96)02697-2

Cited by 139 publications

(82 citation statements)

References 26 publications

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“…The findings were replicated [37][38][39][40][41][42] in FDG-PET studies examining patients both at rest, and while provoking symptoms, although not all studies produced positive findings [43][44][45] . A meta-analysis 46 confirmed abnormalities were present in the orbital gyrus and the head of the caudate in patients with obsessivecompulsive disorder.…”

Section: Evidence From Neuroimaging Studiessupporting

confidence: 66%

Advances in Neuromodulation: The Orbitofrontal-Striatal Model Of, and Deep Brain Stimulation In, Obsessive-Compulsive Disorder

McClure¹

2012

When Things Go Wrong - Diseases and Disorders of the Human Brain

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Section: Evidence From Neuroimaging Studiessupporting

confidence: 66%

Advances in Neuromodulation: The Orbitofrontal-Striatal Model Of, and Deep Brain Stimulation In, Obsessive-Compulsive Disorder

McClure¹

2012

When Things Go Wrong - Diseases and Disorders of the Human Brain

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“…In parallel, the results of neuroimaging studies in OCD patients have implicated dysfunction of the OFC and of the striatum in the pathophysiology of OCD (for review see Saxena et al, 1998;Stein, 2000). The metabolic activity of these two regions was found to be higher in OCD patients compared to healthy controls, to increase during symptom provocation, and to decrease after a successful treatment with selective serotonin reuptake inhibitors (SSRIs; Baxter et al, 1992;Benkelfat et al, 1990;Breiter et al, 1996;Cottraux et al, 1996;Insel, 1992;McGuire et al, 1994;Rauch et al, 1994;Saxena et al, 1999;Swedo et al, 1992). Although the serotonergic system, the OFC, and the striatum are interconnected, the specific abnormality of these regions, as well as the ways in which they interact to produce obsessions and compulsions, is unknown.…”

Section: Introductionmentioning

confidence: 51%

The Role of the Striatum in Compulsive Behavior in Intact and Orbitofrontal-Cortex-Lesioned Rats: Possible Involvement of the Serotonergic System

Schilman

Klavir

Winter

et al. 2010

Neuropsychopharmacol

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In the signal attenuation rat model of obsessive-compulsive disorder (OCD), 'compulsive' behavior is induced by attenuating a signal indicating that a lever-press response was effective in producing food. We have recently found that lesions to the rat orbitofrontal cortex (OFC) led to an increase in compulsive lever-pressing that was prevented by systemic administration of the selective serotonin reuptake inhibitor paroxetine, and paralleled by an increase in the density of the striatal serotonin transporter. This study further explored the interaction between the OFC, the striatum, and the serotonergic system in the production of compulsive lever-pressing. Experiment 1 revealed that OFC lesions decrease the content of serotonin, dopamine, glutamate, and GABA in the striatum. Experiment 2 showed that intrastriatal administration of paroxetine blocked OFC lesion-induced increased compulsivity, but did not affect compulsive responding in intact rats. Experiments 3 and 4 found that pre-training striatal lesions had no effect on compulsive lever-pressing, whereas post-training striatal inactivation exerted an anticompulsive effect. These results strongly implicate the striatum in the expression of compulsive lever-pressing in both intact and OFC-lesioned rats. Furthermore, the results support the possibility that in a subpopulation of OCD patients a primary pathology of the OFC leads to a dysregulation of the striatal serotonergic system, which is manifested in compulsive behavior, and that antiobsessional/anticompulsive drugs exerts their effects, in these patients, by normalizing the dysfunctional striatal serotonergic system.

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“…Studies have also reported similar relationships between subclinical groups compared to patients with regards to deficits in neuropsychological (Mataix-Cols et al, 1999;Sher, Frost, & Otto, 1983;Sher, Mann, & Frost, 1984), memory function (Rubenstein, Peynircioglu, Chambless, & Piggot, 1993), and similarities in task-related brain activity (Cottraux et al, 1996;Mataix-Cols et al, 2003).…”

mentioning

confidence: 86%

Individual Differences Predict Patterns in Spontaneous Involuntary Musical Imagery

Müllensiefen

Fry²,

Jones

et al. 2012

Music Perception

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INVOLUNTARY MUSICAL IMAGERY (INMI) DESCRIBESthe everyday phenomenon of having a tune stuck in the head. Research has established the ubiquity of this form of spontaneous cognition but the predictive role of individual differences is still debated. This study examines the impact of everyday musical behaviors and subclinical obsessive compulsive attributes on INMI experiences. In total 1,536 participants completed three online questionnaires; a novel inventory of musical behavior and INMI, and a standardized obsessive compulsion (OC) inventory. Exploratory factor analysis (N ¼ 512) and structural equation modelling (N ¼ 1,024) were applied. Everyday singing and music listening positively predict length and frequency of reported INMI episodes, respectively. No relationships were found with musical training. High OC was positively related to INMI frequency and disturbance, but only indirectly to INMI episode length and unpleasantness. The identified contributory factors of INMI experiences are discussed in the context of musical memory and spontaneous mental activity.

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A controlled positron emission tomography study of obsessive and neutral auditory stimulation in obsessive-compulsive disorder with checking rituals

Cited by 139 publications

References 26 publications

Advances in Neuromodulation: The Orbitofrontal-Striatal Model Of, and Deep Brain Stimulation In, Obsessive-Compulsive Disorder

Advances in Neuromodulation: The Orbitofrontal-Striatal Model Of, and Deep Brain Stimulation In, Obsessive-Compulsive Disorder

The Role of the Striatum in Compulsive Behavior in Intact and Orbitofrontal-Cortex-Lesioned Rats: Possible Involvement of the Serotonergic System

Individual Differences Predict Patterns in Spontaneous Involuntary Musical Imagery

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