A controlled study of clopamide, clorexolone, and hydrochlorothiazide in diabetics

Hicks, B. H.; Ward, J. D.; Jarrett, R. J.; Keen, H.; Wise, P. H.

doi:10.1016/0026-0495(73)90260-6

Cited by 33 publications

(7 citation statements)

References 30 publications

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“…Prince et al (33) studied 10 NIDDM hypertensive patients and found that, after 4 wk of 25 mg/day hydrochlorthiazide with K + supplementation, fasting glucose, insulin concentrations, and GHb levels did not increase. Three other reports confirmed that lowdose thiazide diuretic therapy did not worsen metabolic control in diabetic hypertensive patients (35, 176,205).…”

Section: Diureticsmentioning

confidence: 75%

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Drug Treatment of Hypertension in Patients With Diabetes Mellitus

Stein

Black

1991

Diabetes Care

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Patients with diabetes mellitus have an increased prevalence of hypertension and its vascular consequences, including coronary and cerebrovascular disease. Drug treatment of hypertension in diabetic subjects is fraught with potential difficulties, including the altered efficacy of medications, the increased risk of side effects, and the possibility of worsening glycemic control and increasing serum lipid levels. Despite these difficulties, treatment is an important part of reducing morbidity and mortality from vascular events. Antihypertensive therapy may also have the potential to prevent or retard the development of diabetic nephropathy. In this article, we discuss the efficacy and metabolic and nonmetabolic side effects of the various classes of antihypertensive agents in patients with diabetes mellitus and suggest a stepped-care approach to the drug treatment of patients with hypertension and diabetes.

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Section: Diureticsmentioning

confidence: 75%

“…In one study of nine NIDDM hypertensive patients, BP was reduced by 20/10 mmHg with 25 mg/day of hydrochlorthiazide (33). In contrast, a low dose of hydrochlorthiazide had only a minimal hypotensive effect (mean BP reduction of 2/5 mmHg) in another study (176).…”

Section: Diureticsmentioning

confidence: 91%

Drug Treatment of Hypertension in Patients With Diabetes Mellitus

Stein

Black

1991

Diabetes Care

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“…Therefore, in short term studies in diabetics, chlorothiazide 1 g/d caused the fasting blood glucose to increase by approximately 1.5 mmol/l, benzthiazide 150 mg by around 3 mmol/l and hydrochlorothiazide 150mg by around 2 mmol/I (Shapiro et al, 1961;Runyan, 1962;Chazan & Boshell, 1965;Goldneretal., 1960). However, in a dose of 25 mg/d, hydrochlorothiazide had no significant effect on the mean blood glucose level (Hicks et al, 1973). Nowadays we tend to use lower doses of thiazide diuretics such as 25 mg/day of hydrochlorothiazide and hence hyperglycaemia may be less of a problem even in diabetics than the original studies of this phenomenon suggested.…”

Section: Thiazide Diureticsmentioning

confidence: 98%

The choice of antihypertensive therapy in the diabetic patient

Struthers

1985

Postgraduate Medical Journal

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“…In hypertensive patients, diuretics (14) and (3-blockers (15) may interfere with carbohydrate metabolism, and in insulin-treated diabetic patients, fJ-blockers may precipitate severe hypoglycemic episodes (16). Consequently, it is important to note that 1 yr of enalapril administration did not significantly alter daily insulin requirements or glycemic control, which was tightly monitored by self-determined capillary glucose and measurements of HbA t .…”

Section: Short-term Trialmentioning

confidence: 99%

Effects of Enalapril in Insulin-Dependent Diabetic Subjects With Mild to Moderate Uncomplicated Hypertension

1987

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The antihypertensive efficacy of enalapril and its effects on the metabolism and kidney function were investigated in 11 insulin-dependent diabetic subjects with uncomplicated mild to moderate hypertension. During a short-term single-blind controlled trial, one daily dose of 20 or 40 mg enalapril significantly reduced both systolic and diastolic blood pressure. In the supine position, mean systolic blood pressure declined from 169 +/- 6 to 142 +/- 6 mmHg (P less than .01) and mean diastolic blood pressure from 101 +/- 1.5 to 85 +/- 2 mmHg (P less than .001). No changes in heart rate or postural hypotension were observed. During 1 yr of treatment, the antihypertensive efficacy of enalapril did not decline, and no clinical side effects were observed. Inhibition by enalapril of angiotensin-converting enzyme did not modify daily insulin requirements, glycemic control, uricemia, or lipid metabolism; kalemia and the markers of diabetic nephropathy were not significantly altered. These results suggest that enalapril once daily should be used as the first step in the treatment of diabetic patients with mild to moderate hypertension.

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A controlled study of clopamide, clorexolone, and hydrochlorothiazide in diabetics

Cited by 33 publications

References 30 publications

Drug Treatment of Hypertension in Patients With Diabetes Mellitus

Drug Treatment of Hypertension in Patients With Diabetes Mellitus

The choice of antihypertensive therapy in the diabetic patient

Effects of Enalapril in Insulin-Dependent Diabetic Subjects With Mild to Moderate Uncomplicated Hypertension

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