A controlled study of consumption of β-glucan-enriched soups for 2 months by type 2 diabetic free-living subjects

Abstract

Type 2 diabetes is associated with a higher cardiovascular risk and there has been a growing interest in using dietary intervention to improve lipid profile and glucose control. The present work aims at analysing the effects of the enrichment of a normal diet with b-glucan (3·5 g/d) in free-living type 2 diabetic subjects for 2 months, using a palatable soup. This trial was a parallel, placebo-controlled, double-blinded randomised study performed in fifty-three type 2 diabetic subjects. During a 3-week run-in period, subjects daily consumed a ready meal control soup (without b-glucan). For the following 8 weeks, subjects were randomly assigned to consume daily either a control soup or a b-glucan soup. Changes in lipid profile (total cholesterol (TC), HDL-and LDL-cholesterol (HDLc and LDLc), apo B and TAG) and in glucose control (HbA1c and fasting glucose) were measured. There was no significant alteration in lipid profile in the two groups (TC, HDLc, LDLc and apo B). TAG decreased significantly in the b-glucan group compared with the control group (2 0·12 (SD 0·38) v. 0·12 (SD 0·44) mmol/l, P¼ 0·03). HbA1c and fasting glucose were not reduced in any group. A single daily ingestion of 3·5 g b-glucan, as required by official dietary recommendations, for 8 weeks did not change the lipid profile and HbA1c in type 2 diabetic subjects. To improve the metabolic profile of type 2 diabetic subjects in the long term, the quantity, the food vectors and the tolerability of b-glucan products may be re-evaluated.

A Systematic Review of the Efficacy of Bioactive Compounds in Cardiovascular Disease: Carbohydrates, Active Lipids and Nitrogen Compounds

“…The quality scores were between 3 and 4 according to the JADAD scale. Subjects were between 26 and 75 years, with a sample size of 18 and 97 participants [8,18]. Cugnet-Anceau et al [8] evaluated the intake of 3.5 g/day of β-glucans in soup, in T2D patients (BMI of 20-35 kg/m 2 ) for 2 months.…”

“…Epidemiologic studies have suggested that dietary fibres such as β-glucan, a non-starch viscous polysaccharide derived from oat, are known to exhibit hypercholesterolemic effects, furthermore protecting against CHD [8]. …”

Efectos del consumo del beta-glucano de la avena sobre el colesterol sanguíneo: una revisión

“…74 Cugnet-Anceau y Cols. 75 Wolever y Cols. Efectos del consumo del beta-glucano de la avena sobre el colesterol sanguíneo: una revisión Un 78% de los estudios encontraron efectos hipocolesterolemiantes del beta-glucano de avena, lo que coincide con la revisión realizada por Othman y Cols.…”

Evaluate the effect of oat-beta glucan in controlling blood glucose levels among type 2 diabetic individuals

“…As a result, various studies have been done investigating non-pharmacological form of treatments such as physical activity and functional food to reduce the side effect of diabetes. 3 Low glycaemic food consumption is a very fruitful alternative in controlling diabetes. 4 Foods that are rich in fiber are on the top of the glycaemic index and the potential component is beta glucan.…”

“…[5][6][7] Studies have suggested that food products containing beta-glucans could reduce hyperglycemia. 3,4 Reyna et al 2003, suggested that the fiber build a barrier to prevent nutrients including glucose from being absorbed in the small intestine and consequently reducing insulinemia, glycaemia and cholesterol levels. 8 Studies that have been examining the impacts of beta glucans in people who are more likely to develop metabolic syndrome are frequent, however, the evidence of consuming oat beta-glucan to enhance glycaemia and insulin levels are not well established.…”