A controlled study of short-term treatment of tension headache

Kagan, G. Ya.; Masheter, H. C.

doi:10.1185/03007997809110210

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1): they were in chronic TTH [3,28]; 84% of patients had migraine [14]; rectal administration [26]; duplicate publication [38,80]; not randomised and double-blind [5,54,70]; without initial pain of at least moderate intensity, which can reduce sensitivity [12,13,15,16,33,65]; or not full publications [1]. Copies of 2 other publications (45 patients in total) could not be obtained [58,71].…”

Section: Searchingmentioning

confidence: 98%

Evidence for efficacy of acute treatment of episodic tension-type headache: Methodological critique of randomised trials for oral treatments

Moore

Derry

Wiffen

et al. 2014

Pain

View full text Add to dashboard Cite

The International Headache Society (IHS) provides guidance on the conduct of trials for acute treatment of episodic tension-type headache (TTH), a common disorder with considerable disability. Electronic and other searches identified randomised, double-blind trials of oral drugs treating episodic TTH with moderate or severe pain at baseline, or that tested drugs at first pain onset. The aims were to review methods, quality, and outcomes reported (in particular the IHS-recommended primary efficacy parameter pain-free after 2 hours), and to assess efficacy by meta-analysis. We identified 58 reports: 55 from previous reviews and searches, 2 unpublished reports, and 1 clinical trial report with results. We included 40 reports of 55 randomised trials involving 12,143 patients. Reporting quality was generally good, with potential risk of bias from incomplete outcome reporting and small size; the 23 largest trials involved 82% of patients. Few trials reported IHS outcomes. The number needed to treat values for being pain-free at 2 hours compared with placebo were 8.7 (95% confidence interval [CI] 6.2 to 15) for paracetamol 1000 mg, 8.9 (95% CI 5.9 to 18) for ibuprofen 400mg, and 9.8 (95% CI 5.1 to 146) for ketoprofen 25mg. Lower (better) number needed to treat values were calculated for outcomes of mild or no pain at 2 hours, and patient global assessment. These were similar to values for these drugs in migraine. No other drugs had evaluable results for these patient-centred outcomes. There was no evidence that any one outcome was better than others. The evidence available for treatment efficacy is small in comparison to the size of the clinical problem.

show abstract

Section: Searchingmentioning

confidence: 98%

Evidence for efficacy of acute treatment of episodic tension-type headache: Methodological critique of randomised trials for oral treatments

Moore

Derry

Wiffen

et al. 2014

Pain

View full text Add to dashboard Cite

show abstract

“…The frequent discomfort of muscle-contraction headache is commonly and successfully treated with over-the-counter (OTC) analgesics. [1][2][3][4][5][6] Although several clinical trials [7][8][9] have shown the efficacy of OTC doses of ibuprofen in muscle-contraction headache, the onset of ibuprofen's action has not been addressed. The current research was conducted to evaluate this important pharmacodynamic property.…”

Section: Introductionmentioning

confidence: 99%

Onset of Action of Ibuprofen in the Treatment of Muscle‐Contraction Headache

Schachtel

Thoden

1988

Headache

View full text Add to dashboard Cite

SYNOPSIS A double‐blind, randomized, placebo‐controlled trial was conducted to determine the onset of action of ibuprofen 400 mg in the treatment of muscle‐contraction headache. Because this represents a non‐prescription dosage of this analgesic, we evaluated subjects with a history of recurrent muscle‐con‐traction headaches that were amenable to over‐the‐counter analgesic therapy. Headache pain intensity was evaluated on a visual analog scale, and pain relief was measured on a categorical scale 15, 30, 45, 60, 90, and 120 minutes after a single 400‐mg dose of ibuprofen or placebo. Efficacy was detected within 15 minutes on the pain intensity rating scale (P<0.05) and within 30 minutes and at all subsequent time points on both the pain intensity and pain relief rating scales (P<0.001). These results indicate an early onset of action of ibuprofen 400 mg in the treatment of muscle‐contraction headache.

show abstract

Zum Stoffwechsel des Doxylamin: Isolierung, Identifizierung und Synthese einiger Metabolite

Gielsdorf¹,

Schubert²

1981

CCLM

View full text Add to dashboard Cite

Zusammenfassung: Nach Einnahme therapeutischer Dosen von Doxylamin konnten im menschlichen Harn mit Hilfe chromatographischer und spektroskopischer Methoden -neben der unveränderten Ausgangsbindung (I) -fünf weitere Ausscheidungsprodukte nachgewiesen werden, deren chemische Strukturen diskutiert und z.T. durch Synthesen bewiesen wurden.Wie die vorliegenden Ergebnisse zeigen, sind bei der Biotransformation des Doxylamins beim Menschen folgende Abbauwege zu erkennen: Neben den sukzessiven Desalkylierungen am Stickstoff, die über das N-Desmethyl-doxylamin(II) zum N,N-Didesmethyl-doxylamin(III) führen, sind dies Spaltungen an der Benzhydrylether-Gruppe, die zu den Abbaupro-führen. Für VI und VII muß jedoch eine Artefaktbildung bedacht werden.Für ein weiteres Abbauprodukt (IV) war eine eindeutige Strukturzuordnung aufgrund der geringen Substanzmenge nicht möglich.Das analytische Verhalten (Hydrolyse!) der Reinsubstanz und freien Base wird ebenso eingehend diskutiert wie die Rolle der chemischen lonisations-Massenspektrometrie mit verschiedenen Reaktandgasen bei der Untersuchung biologischer Extrakte. Biotransformation ofdoxylamine: Isolation, identification and synthesis of some metabolitesSummary: After administration of therapeutic doses ofdoxylamine, the unchanged drug(I) and five degradation products were detected in human urine; their chemical structures are discussed and -to some extent -confirmed by synthesis. The results show that biotransformation ofdoxylamine in man takes place by the following routes: successive dealkylatipns at the nitrogen atom, giving N-demethyl-doxylamine(II) and N.N-didemethyl-doxylamine(II); cleavage at the benzhydrylether-function, resulting in the formation of l-phenyl-l-(2-pyridyl)-ethanol(V), 1-phenyll-(2Tpyridyl)^thane(VI) and l-phenyl-l<2-pyridyl)-ethene(VII). VI and VII may be artefacts. Identification of an additional degradation product(=iV) was not possible, because the isolated quantities were too small.

show abstract

A controlled study of short-term treatment of tension headache

Cited by 3 publications

References 0 publications

Evidence for efficacy of acute treatment of episodic tension-type headache: Methodological critique of randomised trials for oral treatments

Evidence for efficacy of acute treatment of episodic tension-type headache: Methodological critique of randomised trials for oral treatments

Onset of Action of Ibuprofen in the Treatment of Muscle‐Contraction Headache

Zum Stoffwechsel des Doxylamin: Isolierung, Identifizierung und Synthese einiger Metabolite

Contact Info

Product

Resources

About