A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis

Fung, Adrian Y. P.; Look, Paul C. N.; Mrcpi, .; Chong, Lai Yin; Fhkam, .; But, Paul Pui Hay; Wong, Eric; Ma, Zhenqiang

doi:10.1046/j.1365-4362.1999.00732.x

Cited by 91 publications

(71 citation statements)

References 26 publications

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“…TCM may have some benefit for AD lesions, but the results are conflicting and reports on serious hepatotoxicity raise potential safety concerns. Well-designed, placebo-controlled clinical trials are warranted to evaluate the efficacy and safety of the use of TCM in adult AD [2,3,[39][40][41][42][43][44][45].…”

Section: Discussionmentioning

confidence: 99%

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Is the alternative medicine a real alternative in adult atopic dermatitis? Experiences of 125 patients

Pónyai¹,

Temesvári²,

Kárpáti³

2016

Glob Dermatol

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Section: Discussionmentioning

confidence: 99%

“…As side-effects, reversible liver enzyme increase, hepatotoxicity, reversible dilatative cardiomyopathy have been reported, mild abdominal pain and headache were observed. One should consider pregnancy, breastfeeding, childhood, liver and heart diseases as contraindication of TCM [12,[39][40][41][42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Is the alternative medicine a real alternative in adult atopic dermatitis? Experiences of 125 patients

Pónyai¹,

Temesvári²,

Kárpáti³

2016

Glob Dermatol

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“…In 2005, the efficacy of these treatments was assessed by a Cochrane Collaboration review, 22 including four randomized controlled trials (RCTs) up to the year 2004. 9,13,23,24 According to the review, herbal mixtures may be effective for the treatment of AD. However, four small, poorly reported RCTs using the same product, Zemaphyte, were found to be inconclusive.…”

Section: Tj-15 Tj-17 For Ad and Pattern Identificationmentioning

confidence: 99%

“…However, four small, poorly reported RCTs using the same product, Zemaphyte, were found to be inconclusive. 23 In addition, the side-effects associated with Zemaphyte raised concerns about potential hepatic and renal toxicity. 25 For methodological reasons, all of the previous studies mentioned previously have used the same herbal formula for all patients.…”

Section: Tj-15 Tj-17 For Ad and Pattern Identificationmentioning

confidence: 99%

The Effect of TJ-15 Plus TJ-17 on Atopic Dermatitis: A Pilot Study Based on the Principle of Pattern Identification

Choi

Kim

et al. 2012

The Journal of Alternative and Complementary Medicine

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Aim: Hwang-Yeon-Hae-Dok-San (TJ-15) and Ou-Ryung-San (TJ-17) are two common herbal formulas that have been used to treat atopic dermatitis (AD), especially the Dampness-Heat pattern of AD. The aim of this study was to determine the safety and efficacy of TJ-15 plus TJ-17 for patients with the Dampness-Heat pattern of AD based on pattern identification. Methods: This study was a parallel, randomized, active-controlled, double-blind trial. A total of 24 patients were enrolled. Either a combination of TJ-15 plus TJ-17, or TJ-15 alone was orally administered 3 times daily for 4 weeks. Of the patients enrolled, 19 patients completed the 4-week treatment course (TJ-15 plus TJ-17: n = 8, TJ-15: n = 11). Efficacy was assessed using the scoring atopic dermatitis (SCORAD) index; area of eczema and severity index (EASI); as well as the symptoms related to the Dampness-Heat by pattern identification. Efficacy measures were evaluated at the baseline and at 4 weeks. Safety was assessed throughout the study using ongoing laboratory tests. Results: Both the SCORAD and EASI showed more improvement in the TJ-15 plus TJ-17 group than in the TJ-15 group; however, the differences were not statistically significant. The symptoms related to the Dampness-Heat pattern were reduced in both groups, and the changes were similar. There were no reported adverse events during this study, or abnormalities observed on aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and creatinine testing. Conclusions:The results of this study suggest that both the TJ-15 plus TJ-17 and the TJ-15 provided safe and effective treatment for patients with the Dampness-Heat pattern type of AD.

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“…It should however be heeded that these changes are only a reflection of clinical improvement and need not be a direct effect of Chinese herbal tea. In contrast to these European studies, a recent double-blind, placebo-controlled, crossover study among Chinese AD patients from Hong Kong failed to show efficacy of Chinese herbal tea therapy over placebo during a 20-week period, except for an improvement of lichenification at visits on week 4 [29]. Ethnic differences may explain these differences.…”

Section: Chinese Herbal Teamentioning

confidence: 99%

Novel Unconventional Therapeutic Approaches to Atopic Eczema

Worm

Henz²

2000

Dermatology

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Atopic eczema is a chronic, recurrent, multifactorial skin disease, and, accordingly, there are numerous therapeutic options for its symptomatic treatment. Conventional medications are however often unsatisfactory for many patients because of adverse effects on long-term use. For this reason, patients often readily welcome unconventional therapeutic approaches. We present here a selected number of such treatment modalities, namely γ-linolenic acid, Chinese herbal tea, diets eliminating allergens, pseudoallergens, metal salts and sodium, and bioresonance. When stringent scientific criteria are applied in the evaluation of such study results, none of the reviewed alternative treatments provides unequivocal, convincing evidence of its efficacy, even when double-blind, placebo-controlled studies are available. With Chinese herbal tea, potentially serious adverse effects should be considered as well. Any new type of unconventional therapy should thus be thoroughly evaluated and shown to be equal or superior to conventional treatments with regard to both efficacy and tolerability before it is recommended for use in clinical practice.

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A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis

Abstract: Zemaphyte did not seem to benefit Chinese patients with recalcitrant atopic dermatitis in our study. Further research is required to evaluate its efficacy.

Cited by 91 publications

References 26 publications

Is the alternative medicine a real alternative in adult atopic dermatitis? Experiences of 125 patients

Is the alternative medicine a real alternative in adult atopic dermatitis? Experiences of 125 patients

The Effect of TJ-15 Plus TJ-17 on Atopic Dermatitis: A Pilot Study Based on the Principle of Pattern Identification

Novel Unconventional Therapeutic Approaches to Atopic Eczema

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