A controlled trial of traditional Chinese medicinal plants in widespread non-exudative atopic eczema

Sheehan, Mary P.; Atherton, D.J.

doi:10.1111/j.1365-2133.1992.tb07817.x

Cited by 254 publications

(135 citation statements)

References 12 publications

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“…Some 7000 different plant species are used in China and preparations may vary extremely with regard to composition and dosage 9 . An intense discussion of Chinese herbal medicine resulted from the examination of the ef®cacy of treatment of atopic dermatitis 10,11 . In a reaction to dermatological studies, a number of reports were published showing acute hepatitis after the treatment of eczema with Chinese herbal decoctions containing various plant extracts 12±16 .…”

Section: Chinese Herbal Medicinementioning

confidence: 99%

Hepatotoxicity of botanicals

Stickel

Egerer

Seitz

2000

Public Health Nutr.

133

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Objective: Hepatic impairment resulting from the use of conventional drugs is widely acknowledged, but there is less awareness of the potential hepatotoxicity of herbal preparations and other botanicals, many of which are believed to be harmless and are commonly used for self-medication without supervision. The aim of this paper is to examine the evidence for hepatotoxicity of botanicals and draw conclusions regarding their pathology, safety and applications. Design: Current literature on the hepatotoxicity of herbal drugs and other botanicals is reviewed. The aetiology, clinical picture and treatment of mushroom (Amanita) poisoning are described.

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Section: Chinese Herbal Medicinementioning

confidence: 99%

Hepatotoxicity of botanicals

Stickel

Egerer

Seitz

2000

Public Health Nutr.

133

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“…Patients were recruited by a local advertisement and ads on hospital bulletin boards. Among those screened (n = 60), all patients were diagnosed according to Hanifin and Rajka's criteria, 18 and were diagnosed with the Dampness-Heat pattern type of AD 9,13 according to pattern identification by a TKM dermatology specialist. Subjects with the following were excluded: patients taking antihistamines and/or steroids within 4-weeks prior to the study; patients with seizures; pregnant or lactating patients; and those with serious medical conditions, including infections.…”

Section: Subjectsmentioning

confidence: 99%

“…In 2005, the efficacy of these treatments was assessed by a Cochrane Collaboration review, 22 including four randomized controlled trials (RCTs) up to the year 2004. 9,13,23,24 According to the review, herbal mixtures may be effective for the treatment of AD. However, four small, poorly reported RCTs using the same product, Zemaphyte, were found to be inconclusive.…”

Section: Tj-15 Tj-17 For Ad and Pattern Identificationmentioning

confidence: 99%

“…5,6 The increase in the use of herbal medicine is associated with both doctors' and patients' dissatisfaction with some aspects of the conventional treatment for AD, 7 especially now that a number of studies have demonstrated the safety and efficacy of herbal medicine for treating AD. [8][9][10][11][12][13] Most studies on herbal medicine for AD, however, have used fixed herbal formulae that have not considered one of the fundamental principles of herbal medicine, that being pattern identification (bian zheng). According to the World Health Organization, pattern identification is defined as the overall analysis of clinical data to determine the location, cause, and nature of a patient's disease and the diagnosis for any such given pattern.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of TJ-15 Plus TJ-17 on Atopic Dermatitis: A Pilot Study Based on the Principle of Pattern Identification

Choi

Kim

et al. 2012

The Journal of Alternative and Complementary Medicine

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Aim: Hwang-Yeon-Hae-Dok-San (TJ-15) and Ou-Ryung-San (TJ-17) are two common herbal formulas that have been used to treat atopic dermatitis (AD), especially the Dampness-Heat pattern of AD. The aim of this study was to determine the safety and efficacy of TJ-15 plus TJ-17 for patients with the Dampness-Heat pattern of AD based on pattern identification. Methods: This study was a parallel, randomized, active-controlled, double-blind trial. A total of 24 patients were enrolled. Either a combination of TJ-15 plus TJ-17, or TJ-15 alone was orally administered 3 times daily for 4 weeks. Of the patients enrolled, 19 patients completed the 4-week treatment course (TJ-15 plus TJ-17: n = 8, TJ-15: n = 11). Efficacy was assessed using the scoring atopic dermatitis (SCORAD) index; area of eczema and severity index (EASI); as well as the symptoms related to the Dampness-Heat by pattern identification. Efficacy measures were evaluated at the baseline and at 4 weeks. Safety was assessed throughout the study using ongoing laboratory tests. Results: Both the SCORAD and EASI showed more improvement in the TJ-15 plus TJ-17 group than in the TJ-15 group; however, the differences were not statistically significant. The symptoms related to the Dampness-Heat pattern were reduced in both groups, and the changes were similar. There were no reported adverse events during this study, or abnormalities observed on aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and creatinine testing. Conclusions:The results of this study suggest that both the TJ-15 plus TJ-17 and the TJ-15 provided safe and effective treatment for patients with the Dampness-Heat pattern type of AD.

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“…In addition, modern tissue culture methods can produce active CM principals such as ginseng and shikonin (used for burns, inflammation and wounds, and also in cosmetics) 53±55 in large quantities over a period of several months. Finally, controlled clinical trials of CM 56,57 have been documented in Western medical journals, as has the validity of synergy between components of a medicinal plant 58 .…”

Section: Formulations and Extractsmentioning

confidence: 99%

Research and future trends in the pharmaceutical development of medicinal herbs from Chinese medicine

Lee

2000

Public Health Nutr.

106

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Issues concerning the past and future development of medicinal herbs from Chinese medicine (CM) are addressed in this paper. In the Western world, medicinal herbs are becoming increasingly popular and important in the public and scientific communities. In contrast to their regulated status in China and other countries, herbal medicines are regarded as dietary supplements in the US. Accordingly, research must continue worldwide to identify and improve the efficacy of the active principals of herbs both singly and in combination ± from active ingredients, active fractions, and active herbal formulations. While Western medicine currently employs pure, single compounds, either natural or synthetic, CM has long used multiple combinations of compounds in the form of processed natural products, primarily medicinal herbs, to treat and relieve the symptoms of many different human diseases. CM may have fewer and less severe side effects than single pure drugs, making CM especially attractive to the consumer. In effect, CM's focus on combination therapy does serve both ancient and modern theories. However, research using modern analytical and chemical techniques is needed to ensure efficacy and safety, to provide qualitative and quantitative analyses for dietary supplements, and to develop new, effective and safe world-class drugs. Drug design is an iterative process. Bioactivity-directed fractionation and isolation identify active natural compounds from single herbs or formulations. These lead structures can be chemically modified and improved through knowledge of structure±activity relationship, mechanism of action, drug metabolism, molecular modelling and combinatorial chemistry studies. Finally, efficacy and toxicity determination as well as clinical trials can contribute to the generation of new drugs from CM. To continue the legacy of CM, as well as the worldwide uses of other medicinal herbs, continued investigation of active formulations, bioactive fractions, and isolated compounds is critical to drug development in the 21st century.

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A controlled trial of traditional Chinese medicinal plants in widespread non-exudative atopic eczema

Cited by 254 publications

References 12 publications

Hepatotoxicity of botanicals

Hepatotoxicity of botanicals

The Effect of TJ-15 Plus TJ-17 on Atopic Dermatitis: A Pilot Study Based on the Principle of Pattern Identification

Research and future trends in the pharmaceutical development of medicinal herbs from Chinese medicine

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