A convenient and mild one pot synthesis of cyclopentenone derivatives

Moger, Manjunath; Pradhan, Ashok Kumar; Hindupur, Rama Mohan; Pati, Hari N.

doi:10.1016/j.tetlet.2014.03.038

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“…anti-microbial 7 , anti-mitotic 8 , cytotoxic 9 and anti-pigment 10 activities. In continuation of our work on cyclopentenone derivatives 11 , herein we wish to report synthesis of new class of aryl substituted and hetero aryl cyclopentenone derivatives and their antimicrobial activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Evaluation of Some Substituted-3-Aryl -2,3,4,5,6,7-hexahydro-1H-inden-1-one

2014

Chem Sci Trans

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Synthesis of new cyclopentenone derivatives by reacting 1-acetyl-1-cyclohexene with various aromatic and heteroaromatic aldehydes is reported. All the new cyclopentenone derivatives were characterized by 1 H, 13 C NMR, IR and mass spectral data, and were further screened for their antimicrobial activity. Most of the compounds showed comparable activities with standard drug ciprofloxacin and in particular, compounds 3d, 3f, 3g and 3j showed excellent activity against all the four bacterial strains.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Evaluation of Some Substituted-3-Aryl -2,3,4,5,6,7-hexahydro-1H-inden-1-one

2014

Chem Sci Trans

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“…Compound 1a has been previously utilized for tandem cyclization reactions with imines and nitroolefins 9 and recently in the synthesis of cyclopentenone derivatives. 10 Surprisingly, however no chiral transformation has been reported using it. 11 Initially we started screening catalysts with primary aminethiourea I and II for the reaction of 1 with nitrostyrene (2a) using toluene as the solvent and 2-fluorobenzoic acid as the co-catalyst.…”

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confidence: 99%