A Convenient and Regioselective Synthesis of 4-Trifluoromethylpyridines

Preparation of α,β-unsaturated trifluoromethylketones and their application in the synthesis of heterocycles

“…127 The reaction of the enone 391 with -aminocrotononitrile results in the formation of 6-trifluoromethyldihydropyridine 392 in a low yield; oxidation of this product leads to the corresponding aromatic derivative 393. 128 …”

Novel and Efficient Synthesis of 7-Trifluoromethyl-Substituted Pyrazolo[1,5-a] Pyrimidines with Potent Antitumor Agents

“…A total of five different trifluoromethyl-β-diketones 1 a-e were synthesized as reported 9 and used in this work. The choice of these particular-β-diketones was determined by their synthetic accessibility.…”

Regioselective synthesis of 6-trifluoromethyl-1,4,5,6-tetrahydropyrazolo[3,4-b]pyran derivatives

“…The crystal data of 4c: 4 ) and concentrated in vacuo. The residue was chromatographed over silica gel, eluted with hexane/ethyl acetate (5/1) to give 4a as a sole product.…”

“…Thus, trifluoromethyl-substituted compounds are becoming increasingly important for the development of new agrochemicals and medicines. In recent years, the synthesis of fluorinated Oheterocyclic or N-heterocyclic compounds have draw much attention [4][5][6]. The b-ketoesters are well established as synthetic intermediates in heterocyclic chemistry [7].…”

“…In this paper, we wish to report the preparation of 6-(trifluoromethyl)-1,4,5,6-tetrahydropyrazolo [3,4-b]pyran derivatives (4) in the presence of ammonium acetate in good to excellent yields.…”