A Convenient FeCl₃-Catalyzed Hydroarylation of Styrenes

Abstract

[reaction: see text] 1,1-Diarylalkanes are easily synthesized by CH-functionalization reactions of electron-rich arenes and heteroarenes with styrenes in the presence of FeCl(3) as catalyst.

A General and Efficient Iron‐Catalyzed Benzylation of 1,3‐Dicarbonyl Compounds

“…Furthermore, by variation of the electrophilic reagent a 100 %-atom efficient addition of aromatic olefins to arenes was realized. [2] Based on this work, we became interested in the direct benzylation of 1,3-dicarbonyl compounds with 1-phenylethanol. The resulting structural motif is found in a number of biologically active compounds (Scheme 1).…”

Development and Initial Application of a Hybridization-Independent, DNA-Encoded Reaction Discovery System Compatible with Organic Solvents

“…26 While this chemistry was recently extended to include the intermolecular hydroarylation of styrenes and simple R-olefins with 1,2-disubstituted indoles, 27 it requires high temperatures and exhibits e2:1 selectivity for the Markovnikov product when styryl olefins are used. Friedel-Crafts-type hydroarylations of styrenes with anisole, thiophene, and xylene nucleophiles under Lewis acid catalysis have also been recently reported, [28][29][30] but require the use of superstoichiometric arene (g4 equiv) and have not been extended to indole nucleophiles.…”

Photoacid Catalyzed Reaction of Phenol with Styrene

“…4,5 Most of these reactions have some drawbacks such as the need for severe reaction conditions (high temperature, strong acidic conditions), low selectivity, moisture sensitivity, high cost, and large amounts of waste materials. 6 Therefore, great efforts have been devoted to search for the more mild reaction conditions such as low temperature, short reaction time, small amounts of catalyst, etc.…”