A convenient guide to help select replacement solvents for dichloromethane in chromatography

Taygerly, Joshua P.; Miller, Larry; Yee, Alicia; Peterson, Emily A.

doi:10.1039/c2gc36064k

Cited by 82 publications

(74 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reaction specific solvent selection guides are now available [87][88][89], which rank a set of solvents according to the observed performance (not greenness). The requirement of the solvent in chromatography as the mobile phase is so obvious in its importance that solvent guides for this application predate all other tools [90,91], and has now been revived as a research topic [92,93]. Technological requirements can be balanced against solvent greenness through general purpose solvent selection guides, and alternative methods of computational solvent optimisation [65,94].…”

Section: Discussionmentioning

confidence: 99%

Tools and techniques for solvent selection: green solvent selection guides

Byrne

Jin

Paggiola

et al. 2016

Sustain Chem Process

1,067

737

View full text Add to dashboard Cite

Driven by legislation and evolving attitudes towards environmental issues, establishing green solvents for extractions, separations, formulations and reaction chemistry has become an increasingly important area of research. Several general purpose solvent selection guides have now been published with the aim to reduce use of the most hazardous solvents. This review serves the purpose of explaining the role of these guides, highlighting their similarities and differences. How they can be used most effectively to enhance the greenness of chemical processes, particularly in laboratory organic synthesis and the pharmaceutical industry, is addressed in detail.

show abstract

Section: Discussionmentioning

confidence: 99%

Tools and techniques for solvent selection: green solvent selection guides

Byrne

Jin

Paggiola

et al. 2016

Sustain Chem Process

1,067

737

View full text Add to dashboard Cite

show abstract

“…Some methods have selected chlorinated solvents as an effective way to extract [28] or separate carotenoids [31]. However, we chose MTBE as a greener alternative to chlorinated solvents [32]. Additionally, our chromatographic separation was mostly based on MeOH.…”

Section: Stationary Phase Selection and Green Chemistrymentioning

confidence: 99%

Simultaneous LC/MS Analysis of Carotenoids and Fat-Soluble Vitamins in Costa Rican Avocados (Persea americana Mill.)

et al. 2019

View full text Add to dashboard Cite

Avocado (a fruit that represents a billion-dollar industry) has become a relevant crop in global trade. The benefits of eating avocados have also been thoroughly described as they contain important nutrients needed to ensure biological functions. For example, avocados contain considerable amounts of vitamins and other phytonutrients, such as carotenoids (e.g., β-carotene), which are fat-soluble. Hence, there is a need to assess accurately these types of compounds. Herein we describe a method that chromatographically separates commercial standard solutions containing both fat-soluble vitamins (vitamin A acetate and palmitate, Vitamin D2 and D3, vitamin K1, α-, δ-, and γ-vitamin E isomers) and carotenoids (β-cryptoxanthin, zeaxanthin, lutein, β-carotene, and lycopene) effectively (i.e., analytical recoveries ranging from 80.43% to 117.02%, for vitamins, and from 43.80% to 108.63%). We optimized saponification conditions and settled at 80 °C using 1 mmol KOH L−1 ethanol during 1 h. We used a non-aqueous gradient that included methanol and methyl tert-butyl ether (starting at an 80:20 ratio) and a C30 chromatographic column to achieve analyte separation (in less than 40 min) and applied this method to avocado, a fruit that characteristically contains both types of compounds. We obtained a method with good linearity at the mid to low range of the mg L−1 (determination coefficients 0.9006–0.9964). To determine both types of compounds in avocado, we developed and validated for the simultaneous analysis of carotenoids and fat-soluble vitamins based on liquid chromatography and single quadrupole mass detection (LC/MS). From actual avocado samples, we found relevant concentrations for cholecalciferol (ranging from 103.5 to 119.5), δ-tocopherol (ranging from 6.16 to 42.48), and lutein (ranging from 6.41 to 15.13 mg/100 g dry weight basis). Simmonds cultivar demonstrated the higher values for all analytes (ranging from 0.03 (zeaxanthin) to 119.5 (cholecalciferol) mg/100 g dry weight basis).

show abstract

“…97 It is worth mentioning that high-speed ball milling has been recognized as an environment-friendly mechanochemical technique given that it enhances atom economy by diminishing or eliminating solvent usage when carrying out organocatalytic reactions. 107 At this point, it is appropriate to mention that recent advances on separation techniques such as supercritical fluid extraction, 108 solid phase extraction, 109 among other practices 110 might permit a greater level of sustainability in chemical reactions in general.…”

Section: Organocatalysis Via Proline Dipeptide Derivatives Assisted Bmentioning

confidence: 99%

Determination of Enantioselectivities by Means of Chiral Stationary Phase HPLC in Order to Identify Effective Proline-Derived Organocatalysts

Vargas-Caporali¹,

Juaristi²

2017

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

The pyrrolidine fragment is a privileged scaffold within chiral ligands employed in coordination complexes exhibiting catalytic activity in asymmetric reactions and, more recently, as enantioselective organocatalysts per se. Likewise, the employment of (S)-proline as starting material constitutes the most direct form to synthesize those chiral derivatives. Afterwards, a preliminary evaluation of the catalytic performance of proline-derived compounds consists of screening many prochiral substrates in well standardized model reactions such as Michael additions and Mannich reactions, with the aim of identifying "broad spectrum" catalysts for more complex synthetic applications. Therefore, a central part of this process involves the fast and direct measurement of enantioselectivities of optically active adducts. The growing development of chiral stationary phases and thus, the wide commercial availability of chiral columns have consolidated high performance liquid chromatography (HPLC) as the preferred technique to identify the most effective catalysts.

show abstract

A convenient guide to help select replacement solvents for dichloromethane in chromatography

Cited by 82 publications

References 16 publications

Tools and techniques for solvent selection: green solvent selection guides

Tools and techniques for solvent selection: green solvent selection guides

Simultaneous LC/MS Analysis of Carotenoids and Fat-Soluble Vitamins in Costa Rican Avocados (Persea americana Mill.)

Determination of Enantioselectivities by Means of Chiral Stationary Phase HPLC in Order to Identify Effective Proline-Derived Organocatalysts

Contact Info

Product

Resources

About