A convenient method for synthesis of bis-2,2′-(1,3,4-thiadiazole) and bis-3,3′-(1,2,4-triazole) derivatives

Synthesis and Characterization of Bisimidazoles, Bistriazoles, Bisthiadiazoles, and Bisthiazoles from Novel Bishydrazonoyl Dichlorides

“…The reactions of bishydrazonoyl halides with thione or 2‐methylthio derivatives have been previously reported . Using these principles to react different thiones or its methylthio derivatives 13a , 13b , 13c with bishydrazonoyl chlorides 5 and 7 in boiling DMF in presence of triethylamine under reflux until hydrogen sulfide or methanethiol ceased to evolve, and working up the reaction mixture gave, in each case, one product as evidenced by TLC analysis.…”

Synthesis of Novel Triazoles, Tetrazine, Thiadiazoles and Their Biological Activities

“…In continuation of our active research in an area of hydrazonoyl halides and their reactions [ 36 , 37 , 38 , 39 , 40 ], a novel compound 4 was prepared by the reaction of salicylaldehyde ( 1 ) with phenylhydrazine ( 2 ) in boiling ethanol to afford salicylaldehydephenylhydrazone ( 3 , Scheme 1 ) [ 41 ]. The hydrazone 3 was then treated with N -bromosuccinimide to give the desired 2-hydroxy- N -phenylbenzohydrazonoyl bromide ( 4 ).…”

A review on bis-hydrazonoyl halides: Recent advances in their synthesis and their diverse synthetic applications leading to bis-heterocycles of biological interest

“…Treatment of the bis -hydrazonoyl chloride I with potassium salts of active methinethioanilides 29A was also reported to give the bis (1,3,4-thiadiazole) derivatives 30A , respectively ( Scheme 23 ) [58] .…”