A Convenient Method for the Synthesis of Phosphorothioates and Their Anticholinesterase Activities

Synthesis of α-oxycarbanilinophosphonates and their anticholinesterase activities: the most potent derivative is bound to the peripheral site of acetylcholinesterase

“…In the continuation of our studies on the synthesis and biological activities of novel organophosphates 29,30 , we decided to investigate to what extent the inhibitory effect of the synthesized α-oxycarbanilinophosphonates toward electric eel AChE would be affected upon the inclusion of different substitutions in the R and R' groups. We have shown, through molecular modelling, the most potent synthesized α-oxycarbanilinophosphonates inhibits AChE through binding to the peripheral site and not to the catalytic site of the enzyme.…”