A convenient method of synthesis of 8-acyl-2,3,6,7-tetrahydro-5Н-[1,3]thiazolo[3,2-c]pyrimidin-5-ones

Thiazolopyrimidine is a nitrogen and sulphur containing heterocyclic aromatic molecule. The bicyclic compound is made by fusing two aromatic rings, thiazole and pyrimidine and replacing one carbon atom with nitrogen and sulphur. The current present work covers a wide range of methods for synthesizing thiazolopyrimidine and its derivatives using a variety of catalysts, solvent medium and microwave irradiation with a goal of achieving a high yield and rapid separation of the product. This article describes the evolution of thiazolopyrimidine as antimicrobial, antiviral, anti-Parkinson, anticancer, anti-inflammatory as well as its structure-activity relationship and potential mode of action for future research. It also includes a list of current patents filed/granted linked to various pharmacological activities in the previous few years.

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A convenient method of synthesis of 8-acyl-2,3,6,7-tetrahydro-5Н-[1,3]thiazolo[3,2-c]pyrimidin-5-ones

Cited by 4 publications

References 10 publications

Activated 2-methylidene-1,3-thiazolidin-4-ones in a promising approach to the synthesis of polyfunctional thiazolo[3,2-c]pyrimidines

Activated 2-methylidene-1,3-thiazolidin-4-ones in a promising approach to the synthesis of polyfunctional thiazolo[3,2-c]pyrimidines

An efficient approach to the synthesis of 7-thioxosubstituted [1,3]thiazolo[3,2-c]pyrimidines and evaluation of their antimicrobial and antioxidant activities

Thiazolopyrimidines: A Retrospective Study of Synthesis, Structure-Activity Relationship and Diverse Pharmacological Actions

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