A Convenient Synthesis of<i>N</i>-Benzylpiperazine, 1-Aralkyl-4-benzylpiperazines and an Isostere of Idebenone

Jin, Wang; Li, Shuo; Hu, Xiangping; Yang, Jian

doi:10.1080/00304948.2014.944409

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Cited by 6 publications

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“…Most of the methods used CoQ 0 as starting material, compound 3 was obtained by reaction with toxic bromine [10], and few syntheses leading to compound 3 have been disclosed [11]. Hence, based on our previous work on the synthesis of CoQ analogues [12][13][14][15][16], we now report an efficient synthetic path for compound 3 as shown in Scheme 2. The reaction is operationally simple and could be used in the preparation of other coenzyme Q analogues.…”

Section: Introductionmentioning

confidence: 99%

Simple and convenient two step synthesis of 5-bromo-2,3-dimethoxy-6-methyl-1,4-benzoquinone

Qiu

Lü

Yan

et al. 2019

Green Processing and Synthesis

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5-bromo-2,3-dimethoxy-6-methyl-1,4-benzoquinone 3, a key intermediate for preparing coenzyme Q compounds, was readily synthesized in two steps by a reaction sequence starting from the commercially available 3,4,5-trimethoxytoluene 1 via bromination and oxidation reactions. Persulfate salts were first employed as oxidants to synthesize 1,4-benzoquinone, the overall yield of title compound 3 was 65%.

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