A Convenient Synthesis of β,β-Difluoro-β-iodo-1-phenylethan-1-ols

Abstract

The synthesis of α,α,α-iodo-difluoromethyl alcohols via the high selective reduction of iododifluoromethyl ketones by NaBH 4 in methanol at 0 ℃ was reported. The reaction has some advantages, such as mild condition, simple synthetic route, and high yield. A convenient way to synthesize more difluoromethylation agents was provided.