A convenient synthesis of the enantiomerically pure (<i>S</i>)-2,4-dihydroxybutyl-4-hydroxybenzoate using hydrolytic kinetic resolution

In the present work, we have synthesized novel quinoline-conjugated 1,2,3-triazole derivatives 6a-l starting from substituted acetanilides in five steps. The synthesized compounds were screened for their antileishmanial activity. Quinoline-conjugated 1,2,3-triazole compounds 6c (IC 50 = 15.1 μg/ml), 6d (IC 50 = 14.6 μg/ml) and 6e (IC 50 = 14.3 μg/ml) displayed potent antileishmanial activity when compared with standard sodium stibogluconate (IC 50 = 14.3 ± 1.5 μg/ml). A molecular docking study against Leishmania major pteridine reductase (Lm-PTR1) suggests that these compounds have the potential to become lead molecules in antileishmanial drug discovery.

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Synthesis, biological evaluation and molecular docking studies of quinoline‐conjugated 1,2,3‐triazole derivatives as antileishmanial agents

Tapkir

Patil

Galave

et al. 2021

Journal of Heterocyclic Chem

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Smith

et al. 2024

Liquid Crystals

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et al. 2020

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A convenient synthesis of the enantiomerically pure (S)-2,4-dihydroxybutyl-4-hydroxybenzoate using hydrolytic kinetic resolution

Cited by 3 publications

References 13 publications

Synthesis, biological evaluation and molecular docking studies of quinoline‐conjugated 1,2,3‐triazole derivatives as antileishmanial agents

Synthesis, biological evaluation and molecular docking studies of quinoline‐conjugated 1,2,3‐triazole derivatives as antileishmanial agents

Synthesis and examination of alkoxycyanobiphenyl mesogens with a single fluorine atom at specific locations in the tail

A Modified Synthesis of Oxetan-3-ol

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