A Convenient Synthesis of Thiazolo [ 3,2-a } - & Triazolo [ 4,3-a ]- Pyrimidines & Pyrimido [ 2,1-c ] Triazine Derivatives

Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation

“…Pyrazolones are also well known elicitor of hypersensitivity [4]. A class of new compounds with pyrazolone moiety was synthesized and reported for their antibacterial, antifungal activities by Al-Haiza et al [5]. A new pyrazolone derivative, edaravone (3-methyl-1-phenyl-2-pyrazoline-5-one) is being used as a drug in clinical practice for brain ischemia [6,7] and also found to be effective against myocardial ischemia [8].…”

Highly efficient catalyst-free domino conjugate addition, decarboxylation and esterification/amidation of coumarin carboxylic acid/esters with pyrazolones: a green chemistry approach

“…On the other hand, pyrazolones are also an important class of compounds in synthetic and medicinal chemistry. These derivatives show numerous bioactivities such as edaravone is marketed as a drug for treating brain and myocardial ischemia, 17 and has antitumor, 18 anti-tubercular, 19 anti-inammatory, 20 antifungal, 21 antibacterial, 22 antimycobacterial, 23 antilarial 24 and antidepressant 25 activities.…”

A Facile Solvent-Free Route for One-Pot Multicomponent Synthesis of Benzylpyrazolyl Coumarins Derivatives in Presence of Effective Synergetic Catalytic System

“…In addition, pyrazolones have kinase inhibitory effects, particularly in the case of enzymes which catalyze both phosphorylation of serine and threonine in proteins. They are also used for treating diseases related to these enzymes, such as rheumatoid arthritis, psoriasis, bone loss, cancer and other proliferative diseases including antifungal [18], antimycobacterial [19,20], antibacterial [21], anti-inflammatory [22], antitumor [23], gastric secretion stimulatory [24], antidepressant [25], antifilarial activities [26] and antitubercular activities [27].…”