A convenient way to synthesize comb-shaped chitosan-graft-poly (N-isopropylacrylamide) copolymer

Chen, Chen; Liu, Mingzhu; Gao, Chunmei; Lü, Shaoyu; Chen, Jiucun; Xin, Yu; Ding, Enyong; Yu, Chuanming; Guo, Jing; Cui, Guijia

doi:10.1016/j.carbpol.2012.09.014

Cited by 44 publications

(31 citation statements)

References 41 publications

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“…Chen et al have proposed a four-step route where the grafting reaction was directed towards the C-6 position; the method involves [59]:…”

Section: Synthesismentioning

confidence: 99%

“…Due to the interesting dual-responsive behaviour of Cs-g-PNIPAm copolymers, the properties of these materials have been thoroughly studied using different techniques such as microdifferential scanning calorimetry (μDSC), dynamic light scattering (DLS), NMR, UV-Vis spectroscopy and rheological measurements, among others [46,51,52,54,[58][59][60][62][63][64][65].…”

Section: Propertiesmentioning

confidence: 99%

“…There are evidences that Cs-g-PNIPAm undergoes micellization processes above the phase transition temperature. On the one hand, Chen et al noticed that aqueous solutions of Cs-gPNIPAm (which amino groups were protected during the synthesis) showed pH-dependent behaviour, and at temperatures above the LCST, the copolymer self-assembled into micelles with chitosan core [59]. On the other hand, recent studies have demonstrated that during heating, Cs-g-oligo(NIPAm) copolymers self-assembled into aggregates due to the hydrophobization of NIPAm blocks.…”

Section: Propertiesmentioning

confidence: 99%

See 2 more Smart Citations

Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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Thermosensitive polymers are materials capable of undergoing a reversible phase transition in aqueous media in response to a variation of the temperature. They have attracted high scientific interest for advanced applications in diverse areas, such as biotechnology, biomedical, environmental, food industry and other fields. At the same time, chitosan is a promising marine polysaccharide that has long been used in applications such as drug, peptide or gene delivery systems. Being the most abundant marine polysaccharide, chitin and chitosan do not exhibit thermoresponsive properties, but some of their derivatives do. In the present chapter, the efforts to produce chitosan-based thermosensitive materials are reviewed. Particularly, the properties and applications of chitosan-glycerophosphate thermogelling system are examined; the methods of synthesis of chitosan copolymers grafted with poly(Nisopropylacrylamide) or poly(N-vinylcaprolactam), their physicochemical properties and most of their prominent applications are discussed as well.

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“…Chen et al have proposed a four-step route where the grafting reaction was directed towards the C-6 position; the method involves [59]:…”

Section: Synthesismentioning

confidence: 99%

Section: Propertiesmentioning

confidence: 99%

Section: Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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show abstract

“…living free radical nitroxide-mediated polymerization, atom transfer radical polymerization and reversible addition-fragmentation chain transfer (RAFT) polymerization [30]. Atom transfer radical polymerization (ATRP) refers to a system where equilibrium between dormant species and radicals is established [31]. Reversible addition fragmentation chain transfer (RAFT) is a reversible deactivation of radical polymerization.…”

Section: Chitosan Co-polymersmentioning

confidence: 99%

Chitosan as an Advanced Healthcare Material

Jardine

Sayed

2014

Advanced Biomaterials and Biodevices

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Chitin and chitosan are renewable biopolymers with inherently favourable properties allowing diverse chemical modifi cation that generates novel materials ideal for biomedical applications. Chitin itself has very poor aqueous solubility and hence found limited utility. For this reason the use of chitosan, in particular, modifi ed chitosan, has increased exponentially in biomedical applications in recent years. Th e review of chitosan as a health care material includes wound healing or tissue regeneration, drug delivery and antimicrobial studies. Specialist applications are vast and due to the shortened publication process, biomedical applications of chitosan may warrant more frequent reviews.In this review, highlights of recent research on the synthesis and analysis of chitin and chitosan based nanomaterials and nanofi bres will be covered. A detailed review of the synthetic transformation of chitosan that further added value by enabling diverse application has been discussed. Th e value of copolymerization and graft ing of biodegradable synthetic polymers with chitosan in order to improve stability and control of the functional biomaterial has been a major driver in the biotechnological innovation.

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“…14,15 Taking these differences as a basic concept, various pH and temperature responsive polymers were synthesized and utilized as carriers for stimuli-responsive delivery of anti-cancer drugs. [16][17][18][19][20] Though all these reported polymeric nanoparticles have shown tremendous potential for targeted drug delivery, they have a very low drug loading capacity. Among them, due to the closer LCST (32 o C) of PNIPAAm to normal body temperature, biocompatibility and non-toxicity, chitosan-g-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) co-polymer was most extensively studied as a carrier for anticancer drugs to achieve thermo and pH responsive delivery of drugs to the intended sites with minimal or no adverse effects in cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of High Oxaliplatin Loaded CS-g-PNIPAAm Co-Polymeric Nanoparticles for Thermo and pH Responsive Delivery

Patil¹,

Gadad²

2018

IJPER

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Background: Chitosan-g-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) co-polymer was reported as a much efficient drug carrier but it shows very low percentage of drug loading in to the nanoparticles. Objective: The objective of the present study was to develop highly loaded pH and thermo responsive CS-g-PNIPAAm co-polymeric nanoparticles for tumor specific oxaliplatin delivery. Methods: CS-g-PNIPAAm co-polymer was synthesized by surfactant free dispersion copolymerization method and characterized for its structure (FTIR1H NMR), morphology and lower critical solution temperature (LCST). Different drug loading approaches like direct drug loading during polymerization and self-assembly methods were used. In direct drug loading method the chitosan concentration was varied and in self assembly method the polymer ratio and sonication time were varied for study. Drug loaded nanoparticles were evaluated for particle size, zeta potential, percent drug loading efficiency, percent drug content and in-vitro drug release study. Results: It was observed that, self-assembly method give a high amount of oxaliplatin loaded nanoparticles. Further, in direct loading method, as the concentration of chitosan in co-polymer increases, the percent drug loading and drug release at above LCST of copolymer also increases. Nanoparticles prepared by self assembly method (F-5) showed the maximum drug release at above LCST (pH 7.2) and trace amount of drug release below LCST (pH 7.5), indicating thermo and pH responsive delivery of oxaliplatin. Conclusion: In conclusion, higher oxaliplatin loading can be achieved by using self-assembly method with sonication time 5 min and drug:polymer ratio of about 3:10 and oxaliplatin release can be controlled by varying chitosan concentration in co-polymer.

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A convenient way to synthesize comb-shaped chitosan-graft-poly (N-isopropylacrylamide) copolymer

Cited by 44 publications

References 41 publications

Chitosan-Based Thermosensitive Materials

Chitosan-Based Thermosensitive Materials

Chitosan as an Advanced Healthcare Material

Development and Evaluation of High Oxaliplatin Loaded CS-g-PNIPAAm Co-Polymeric Nanoparticles for Thermo and pH Responsive Delivery

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