A convergent synthetic platform of gold/silica nanomaterials functionalized gelatin/chitosan hydrogel framework for the bone fracture treatment

Lin, Meng; Zhang, Jiangnan; Li, Jun; Zhang, Dechun; Mo, Tingting

doi:10.1080/17458080.2022.2087872

Cited by 5 publications

(4 citation statements)

References 67 publications

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“…The staining analysis also confirmed biocompatibility in cells, and no adverse effects resulting from the use of such a modified hydrogel were observed. The assessment of fractures in an animal model also confirmed the properties of G/C‐Au@SiO 2 , which is to improve the ability to heal wounds, and the histopathological assessment also confirmed this [185] . Li et al.…”

Section: Medical Application Of Ag/au@silica Core‐shell Nanostructuresmentioning

confidence: 55%

“…The assessment of fractures in an animal model also confirmed the properties of G/C-Au@SiO 2 , which is to improve the ability to heal wounds, and the histopathological assessment also confirmed this. [185] Li et al combined poly(L-lactic) (PLLA) microspheres with Ag@SiO 2 nanostructures, thus obtaining a PLLA/Ag@SiO 2 composite and examining it for bone regeneration in infected bone tissue defects. Research carried out on rats showing skull defects and bacterial infection shows that after a month, such a composite significantly supported bone regeneration and inhibited bacterial infection.…”

Section: Application In Tissue Engineeringmentioning

confidence: 99%

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Medical Applications of Silver and Gold Nanoparticles and Core‐Shell Nanostructures Based on Silver or Gold Core: Recent Progress and Innovations

Kowalska,

Adamska,

Grobelna

2024

ChemMedChem

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Nanoparticles (NPs) of noble metals such as silver (Ag NPs) or gold (Au NPs) draw the attention of scientists looking for new compounds to use in medical applications. Scientists have used metal NPs because of their easy preparation, biocompatibility, ability to influence the shape and size or modification, and surface functionalization. However, to fully use their capabilities, both the benefits and their potential threats should be considered. One possibility to reduce the potential threat and thus prevent the extinction of their properties resulting from the agglomeration, they are covered with a neutral material, thus obtaining core‐shell nanostructures that can be further modified and functionalized depending on the subsequent application. In this review, we focus on discussing the properties and applications of Ag NPs and Au NPs in the medical field such as the treatment of various diseases, drug carriers, diagnostics, and many others. In addition, the following review also discusses the use and potential applications of Ag@SiO2 and Au@SiO2 core‐shell nanostructures, which can be used in cancer therapy and diagnosis, treatment of infections, or tissue engineering.

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Section: Medical Application Of Ag/au@silica Core‐shell Nanostructuresmentioning

confidence: 55%

Section: Application In Tissue Engineeringmentioning

confidence: 99%

Medical Applications of Silver and Gold Nanoparticles and Core‐Shell Nanostructures Based on Silver or Gold Core: Recent Progress and Innovations

Kowalska,

Adamska,

Grobelna

2024

ChemMedChem

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“…It is worth noting that the combined application of CS and gelatin hydrogels for bone tissue engineering has long been widely investigated in previous studies, ,, some of which also explored its improved applications through the introduction of nanohydroxyapatite, gold/silica nanomaterials, or bioactive glass nanoparticles . However, the biosafety of these modified approaches is questionable.…”

Section: Results and Discussionmentioning

confidence: 99%

Lyophilized Platelet-Rich Fibrin Exudate-Loaded Carboxymethyl Chitosan/GelMA Hydrogel for Efficient Bone Defect Repair

Gan

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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Platelet-rich fibrin (PRF) is an autologous growth factor carrier that promotes bone tissue regeneration, but its effectiveness is restrained by poor storage capabilities, uncontrollable concentration of growth factors, unstable shape, etc. Herein, we developed a photocrosslinkable composite hydrogel by incorporating lyophilized PRF exudate (LPRFe) into the carboxymethyl chitosan methacryloyl (CMCSMA)/gelatin methacryloyl (GelMA) hydrogel to effectively solve the dilemma of PRF. The hydrogel possessed suitable physical properties and sustainable release ability of growth factors in LPRFe. The LPRFe-loaded hydrogel could improve the adhesion, proliferation, migration, and osteogenic differentiation of rat bone mesenchymal stem cells (BMSCs). Furthermore, the animal experiments demonstrated that the hydrogel possessed excellent biocompatibility and biodegradability, and the introduction of LPRFe in the hydrogel can effectively accelerate the bone healing process. Conclusively, the combination of LPRFe with CMCSMA/GelMA hydrogel may be a promising therapeutic approach for bone defects.

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“…However, the poor thermal stability and low mechanical strength of gelatin limited its application in cartilage repair. [5,6,45] Lin et al [46] established a gold/silica hybrid, and nanomaterials (Au/SiO 2 ) were incorporated into a gelatin methacrylate/chitosan matrix to solve this problem. According to the experiments, hydrogel swelling and degradation characteristics were interdependent.…”

Section: Proteinsmentioning

confidence: 99%

Advances in Mechanical Properties of Hydrogels for Cartilage Tissue Defect Repair

Wang

Shi

Lin

et al. 2023

Macromolecular Bioscience

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Numerous factors, such as degeneration and accidents, frequently cause cartilage deterioration. Owing to the absence of blood vessels and nerves in cartilage tissue, the ability of cartilage tissue to heal itself after an injury is relatively low. Hydrogels are beneficial for cartilage tissue engineering owing to their cartilage‐like structure and advantageous properties. Due to the disruption of its mechanical structure, the bearing capacity and shock absorption of cartilage are diminished. The tissue should possess excellent mechanical properties to ensure the efficacy of cartilage tissue repair. This paper discusses the application of hydrogels in the fields of cartilage repair, the mechanical properties of hydrogels used for cartilage repair, and the materials used for hydrogels in cartilage tissue engineering. In addition, the challenges faced by hydrogels and future research directions are discussed.

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A convergent synthetic platform of gold/silica nanomaterials functionalized gelatin/chitosan hydrogel framework for the bone fracture treatment

Cited by 5 publications

References 67 publications

Medical Applications of Silver and Gold Nanoparticles and Core‐Shell Nanostructures Based on Silver or Gold Core: Recent Progress and Innovations

Medical Applications of Silver and Gold Nanoparticles and Core‐Shell Nanostructures Based on Silver or Gold Core: Recent Progress and Innovations

Lyophilized Platelet-Rich Fibrin Exudate-Loaded Carboxymethyl Chitosan/GelMA Hydrogel for Efficient Bone Defect Repair

Advances in Mechanical Properties of Hydrogels for Cartilage Tissue Defect Repair

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