A Cooperative Study of Sarcoidosis in Asia and Africa: Descriptive Epidemiology

Hosoda, Yutaka; Kosuda, Tatsuo; Yamamoto, Masanobu; Hongo, Osamu; Mochizumi, H.; Mikami, R; Homma, Hiroto; S, Fujita; Ohira, I; Izumi, Takako; Kobara, Yiragnima; Yammato, H.; Oshima, Sonoko; Teramatsu, T; Maekawa, Nobuhiro; Tsuji, Satsuki; Soon, Cheong Pak; Sodhy, T. S.; Bovornkitti, Somchai; Chakravarty, S. C.; Yang, Sze-Piao; Gomaa, T. M.

doi:10.1111/j.1749-6632.1976.tb47045.x

Cited by 15 publications

(12 citation statements)

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“…In a study from eight countries of Asia and Africa in 1976, fewer than 30 patients were reported from India, Malaysia, Thailand, Taiwan, and United Arab Emirates, while none from Singapore and Korea [2]. In the recent years, there has been increasing reports from countries like India [3-13], Singapore [14], Malaysia [15], Thailand [16], and Taiwan [17].…”

Section: Reviewmentioning

confidence: 99%

Sarcoidosis in tuberculosis-endemic regions: India

Babu¹

2013

J OPHTH INFLAMM INFECT

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Sarcoidosis is a multisystem inflammatory disease of unknown etiology affecting multiple organs. Earlier reports suggested that sarcoidosis was a disease of the developed world. However, recent reports suggest that the disease is found in the developing countries as well. Clinical, radiological, and histopathological similarities with tuberculosis pose a great challenge in countries endemic for tuberculosis. Mantoux test, high resolution computed tomography, and transbronchial lymph node and lung biopsies are diagnostic modalities, which play an important role in the diagnosis of sarcoid. In this review, we look at the epidemiology of sarcoid in tuberculosis-endemic regions, the sarcoidosis-tuberculosis link, clinical profile, diagnostic modalities, dilemma in the diagnosis, and the treatment of this disease.

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Section: Reviewmentioning

confidence: 99%

Sarcoidosis in tuberculosis-endemic regions: India

Babu¹

2013

J OPHTH INFLAMM INFECT

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“…Genetic tendency, environmental factors and immunologic abnormalities are considered in the pathogenesis of the disease, but the exact cause and the disease pathogenesis have not been fully understood. Numerous studies which concerned the aetiology of sarcoidosis have reported a seasonal variation of sarcoidosis and pointed out an unidentified environmental factor(s) (3)(4)(5)(6)(7)(8)(9)(10)(11). However, these studies and others have never studied the interaction among sarcoidosis seasonality and both age and gender.…”

Section: Introductionmentioning

confidence: 99%

Seasonal variation of the onset of presentations in stage 1 sarcoidosis

Demirkok

Başaranoğlu

Akbilgiç

2006

International Journal of Clinical Practice

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Sarcoidosis is a chronic disease with an unknown aetiology. Our aim was to evaluate the pattern of seasonality of stage 1 sarcoidosis subjects who had symptoms by all cases, by age and by both genders. In this study, we used Roger's test for cyclic variation to prove that this seasonal variation was more than chance. Four hundred ninety-two consecutive patients with sarcoidosis who presented different clinical symptoms were included in this retrospective cohort study. According to the chest X-ray examinations, 185 patients had stage 1, while 307 patients in control group had stage 0, 2, 3 and 4 sarcoidosis. The demographic features, presenting clinical features, course of the disease, initial diagnostic methods and both the month and the age at the initial diagnosis for each patient were analysed on chart reviews. Roger's test for cyclic variation was used to determine the significance of any seasonal variation of incidence. Otherwise, t-test was used. The distribution of cumulative monthly presentations for patients with stage 1 peaked in April (108% above the average) and was lowest in October, November and December (48% below the average) (p < 0.001). Seasonality of the control group peaked in May (84% above the average) and was lowest in August (69% below the average) (p < 0.001). The seasonal pattern of subjects within both groups was influenced by some age groups and by both genders (p < 0.05). Some differences in the amplitude of the seasonal variation by age and by both genders increase the possibility of interactions among age, gender and the disease. Further well-designed and prospective studies are required to better understand the importance of our findings and the pathogenesis of the disease.

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“…Shown are the data for all subjects and separately for men and women, and for subjects aged[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] …”

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Sarcoid arthritis: clinical characteristics, diagnostic aspects, and risk factors

Visser

Vos²,

Zanelli³

et al. 2002

Annals of the Rheumatic Diseases

129

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Objectives: (a) To describe the clinical characteristics of acute sarcoid arthritis and the diagnostic value of its presenting clinical features; (b) to evaluate whether disease onset is seasonal; and (c) to evaluate whether smoking behaviour or the presence of HLA class II alleles is a risk factor for the disease. Methods: 579 consecutive patients with recent onset arthritis who had been newly referred to a rheumatology outpatient clinic were included in a prospective cohort study. The presenting clinical features, the smoking behaviour, and the results of HLA-DQ and HLA-DR DNA typing of 55 patients with sarcoid arthritis, 524 patients with other arthritides of recent onset, and samples of the normal population were compared. Results: In all cases the disease showed a self limiting arthritis and overall good prognosis. The diagnostic ability of a combination of four clinical features-symmetrical ankle arthritis, symptoms of less than two months, age below 40 years, and erythema nodosum-was exceptionally high. When test positivity is defined as the presence of at least three of four criteria the set rendered a sensitivity of 93%, a specificity of 99%, a positive predictive value of 75%, and a negative predictive value of 99.7%. The disease clustered in the months March-July. The disease was negatively associated with smoking (odds ratio (OR) 0.09; 95% confidence interval (95% CI) 0.02 to 0.37) and positively associated with the presence of the DQ2 (DQB1*0201)-DR3 (DRB1*0301) haplotype (OR 12.33; 95% CI 5.97 to 25.48). Conclusion: The disease entity acute sarcoid arthritis has highly diagnostic clinical features. The seasonal clustering, the protective effect of smoking, and the association with specific HLA class II antigens support the hypothesis that it results from exposure of susceptible hosts to environmental agents through the lungs.

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A Cooperative Study of Sarcoidosis in Asia and Africa: Descriptive Epidemiology

Cited by 15 publications

References 1 publication

Sarcoidosis in tuberculosis-endemic regions: India

Sarcoidosis in tuberculosis-endemic regions: India

Seasonal variation of the onset of presentations in stage 1 sarcoidosis

Sarcoid arthritis: clinical characteristics, diagnostic aspects, and risk factors

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