A coordinate-based meta-analysis of acupuncture for chronic pain: Evidence from fMRI studies

Zheng, Yu; Wang, Rongrong; Wei, Wei; Liu, Liying; Wen, Chuanbiao; Yu, Shu-Guang; Guo, Xiaoli; Yang, Jie

doi:10.3389/fnins.2022.1049887

Cited by 12 publications

(7 citation statements)

References 54 publications

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“…Abnormalities in the caudate, thalamus, fusiform gyrus, superior frontal gyrus, and medial prefrontal cortex have been found in patients with CP. These abnormalities have been linked to pain processing, cognitive abnormalities, and emotion regulation functions [59]. Our study further explains how alterations in brain structure and function mediate the relationship between disease course and mood disorders.…”

Section: Discussionsupporting

confidence: 58%

Altered cognitive control network mediates the association between long-term pain and anxiety symptoms in primary dysmenorrhea

Yu,

Yang,

Liu

et al. 2023

NeuroReport

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Neuroimaging studies have demonstrated the association of the cognitive control network (CCN) with the maintenance of chronic pain. However, whether and how dorsolateral prefrontal cortex (DLPFC), a key region within the CCN, is altered in menstrual pain is unclear. In this study, we aimed to investigate alterations in the DLPFC functional connectivity network in patients with primary dysmenorrhea (PDM). The study comprised 41 PDM patients and 39 matched healthy controls (HCs), all of whom underwent a resting-state functional MRI scan during the menstrual stage. All participants were instructed to complete the clinical assessment before the MRI scan. We used the DLPFC as the seed in resting-state functional connectivity (rsFC) analysis to investigate the difference between PDM patients and HCs. Compared to HCs, PDM patients showed increased right DLPFC rsFC at the bilateral lingual gyrus, dorsal anterior cingulate cortex (dACC), and middle cingulate cortex, and decreased left DLPFC rsFC at the right orbital frontal cortex. In addition, increased right DLPFC-bilateral dACC connectivity mediated the association between disease duration and the self-rating anxiety scale (SAS) scores in PDM patients. We confirmed that the DLPFC-dACC rsFC was associated with higher SAS scores, which could mediate the association between disease duration and anxiety symptoms in patients with PDM. Our findings provide central pathological evidence for an abnormal rsFC of the CCN in PDM patients, which may contribute to a better understanding of the neuropathophysiological mechanisms underlying PDM.

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Section: Discussionsupporting

confidence: 58%

Altered cognitive control network mediates the association between long-term pain and anxiety symptoms in primary dysmenorrhea

Yu,

Yang,

Liu

et al. 2023

NeuroReport

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“…34 The abnormality of ALFF/fALFF is thought to be a candidate biomarker for the prognosis of various pain conditions. 35 More than half of the included fMRI studies in this review selected FC as an indicator of the brain network, measuring neuronal activities based on the specific region of interest of the brain, representing neural communication among brain regions. 36 These analytical methods are sensitive and reliable to be used in investigating the cerebral mechanism of acupuncture-related therapy.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture-Related Therapy for Knee Osteoarthritis: A Narrative Review of Neuroimaging Studies

Qu,

Peng,

Xiong

et al. 2024

JPR

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Acupuncture has been widely applied for treating knee osteoarthritis (KOA). Numerous studies have found that acupuncture can effectively alleviate KOA symptoms. With the advancement of neuroimaging techniques, integrating neuroimaging with indepth investigations of acupuncture mechanisms has emerged as a hot topic in traditional Chinese medical neuroscience research. This review aimed to analyze the study design and main findings from neuroimaging studies of acupuncture-related therapy for KOA to provide a reference for future research. Original studies were sourced from English databases (PubMed, Embase, and Cochrane Library) and Chinese databases (Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, the Chongqing VIP database, and Wanfang database). As a result, thirteen articles were ultimately included in this review. Functional magnetic resonance imaging was the most frequently used neuroimaging technique to explore cerebral responses to acupuncture-related therapy for KOA. Findings suggested that acupuncture-related therapy could regulate some brain regions in patients with KOA. Specifically, for acupuncture, it showed that the medial pain pathway and the limbic system were involved in the regulation of KOA. Meanwhile, moxibustion induced a wide range of functional activity throughout the entire brain.

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“…This makes it an essential tool for assessing the immediate therapeutic effects of acupuncture on patients [88] . Task-based fMRI is an essential approach for investigating the underlying mechanisms of acupuncture, as it can reveal both the immediate and long-lasting effects of acupuncture on the brain [89] and assess the hemodynamic blood oxygen level-dependent effects to assess its therapeutic effects [90] . Recently, significant research has been dedicated to exploring acupuncture treatments.…”

Section: Breakthrough In Acupuncture Treatment Evaluation: Leveraging...mentioning

confidence: 99%

Intelligent Acupuncture: Data-driven Revolution of Traditional Chinese Medicine

Bao,

Ding,

Zhang

et al. 2023

Acupuncture and Herbal Medicine

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Acupuncture, a form of traditional Chinese medicine with a history of 2000 years in China, has gained wider acceptance worldwide as a complementary therapy. Studies have examined its effectiveness in various health conditions and it is commonly used alongside conventional medical treatments. With the development of artificial intelligence (AI) technology, new possibilities for improving the efficacy and precision of acupuncture have emerged. This study explored the combination of traditional acupuncture and AI technology from three perspectives: acupuncture diagnosis, prescription, and treatment evaluation. The study aimed to provide cutting-edge direction and theoretical assistance for the development of an acupuncture robot.

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A coordinate-based meta-analysis of acupuncture for chronic pain: Evidence from fMRI studies

Cited by 12 publications

References 54 publications

Altered cognitive control network mediates the association between long-term pain and anxiety symptoms in primary dysmenorrhea

Altered cognitive control network mediates the association between long-term pain and anxiety symptoms in primary dysmenorrhea

Acupuncture-Related Therapy for Knee Osteoarthritis: A Narrative Review of Neuroimaging Studies

Intelligent Acupuncture: Data-driven Revolution of Traditional Chinese Medicine

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