A copper-based metal–organic framework/graphene nanocomposite for the sensitive and stable electrochemical detection of DNA bases

Wang, Xiuyun; Zhang, Jie; Wei, Yuanan; Xing, Tianyu; Cao, Tingting; Wu, Shuo; Zhu, Fenghui

doi:10.1039/c9an02398d

Cited by 37 publications

(9 citation statements)

References 48 publications

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“…29 Previously, an ultrasonic-assisted development of GO/MoS 2 , GO/TiO 2 , and GO/CuMOF had been attempted elsewhere. 25,26,30 The formation of GO/TiS 2 as well as ex situ-synthesized GO and TiS 2 was preliminarily confirmed by UV−visible spectroscopy, as shown in Figure 1a. TiS 2 shows a characteristic broad absorption band close to 361 nm, indicating the existence of large particles in the solution.…”

Section: Resultsmentioning

confidence: 73%

“…Finally, the colloidal dispersion of GO/TiS 2 NC shows a higher negative ζ value (−70 mV) compared to GO and TiS 2 , rendering the ionic charge stability through electrostatic repulsive forces between the nanomaterials . Previously, an ultrasonic-assisted development of GO/MoS 2 , GO/TiO 2 , and GO/CuMOF had been attempted elsewhere. ,, The formation of GO/TiS 2 as well as ex situ -synthesized GO and TiS 2 was preliminarily confirmed by UV–visible spectroscopy, as shown in Figure a. TiS 2 shows a characteristic broad absorption band close to 361 nm, indicating the existence of large particles in the solution .…”

Section: Resultsmentioning

confidence: 93%

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Design of Electrochemically Reduced Graphene Oxide/Titanium Disulfide Nanocomposite Sensor for Selective Determination of Ascorbic Acid

Pal

Bhattacharjee

Das

et al. 2021

ACS Appl. Nano Mater.

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Synthesizing conductive nanocomposites (NCs) for realizing an ultrasensitive biosensor is a prevalent technological thrust. Herein, a simple and unusual design of a sensing platform is documented using electrochemically reduced graphene oxide/titanium disulfide nanocomposite (erGO/TiS 2 NC) for detection of ascorbic acid (AA): a significant neurobiological molecule. The NC is designed via sonolysis of a solution comprising ex situsynthesized GO and TiS 2 and subsequently electrochemically reduced for fabricating the sensing interface. Advanced analytical studies are carried out to support the construction of the erGO/TiS 2 //glassy carbon electrode (GCE). Under the optimal measuring conditions, the sensor offers two linear responses within (i) 0.1 → 1 μM, a limit of detection (LoD) of 30.2 nM (S/N = 3) and a sensitivity of 0.34 μA•μM −1 •cm −2 , and (ii) 1 → 400 μM, a LoD of 91.4 nM and a sensitivity of 0.11 μA•μM −1 •cm −2 for AA. Moreover, the sensor demonstrates high selectivity toward AA over other bioanalytes except for tiny anodic responses of cysteine (7.5%) and dopamine (8.9%). Finally, the practicability of the proposed sensor has been tested for AA in pharmaceutical and human urine samples and validated by high-performance liquid chromatography-mass spectrometry (HPLC-MS). Overall, the sensor demonstrates satisfactory reliability for recovery of AA and can be considered for the diagnosis of clinical samples.

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Section: Resultsmentioning

confidence: 73%

Section: Resultsmentioning

confidence: 93%

Design of Electrochemically Reduced Graphene Oxide/Titanium Disulfide Nanocomposite Sensor for Selective Determination of Ascorbic Acid

Pal

Bhattacharjee

Das

et al. 2021

ACS Appl. Nano Mater.

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“…Moreover, the RSD values of adenine and guanine after 50 consecutive detection cycles were 1.92% and 1.37%, respectively. Therefore, it is possible to use the HKUST-1/ERGO/GCE composite material for adenine and guanine detection in real samples, as well as Herring sperm DNA …”

Section: Applications Of Mofs In Electrochemical Sensing and Biosensingmentioning

confidence: 99%

“…Therefore, it is possible to use the HKUST-1/ERGO/GCE composite material for adenine and guanine detection in real samples, as well as Herring sperm DNA. 79 3.2.1.2. Carbon Nanotubes/MOF Composites.…”

Section: Applications Of Mofs In Electrochemical Sensing and Biosensingmentioning

confidence: 99%

Recent Electrochemical Applications of Metal–Organic Framework-Based Materials

Tajik

Beitollahi

Nejad

et al. 2020

Crystal Growth & Design

125

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Metal−organic frameworks (MOFs), a versatile class of porous materials that exhibit high specific surface areas, controllable structures, and tunable pores, have been identified as a promising platform in the field of electrochemistry in recent years, and researchers have now designed MOFs specific to electrochemical applications. In this review, we describe the recent uses of MOFs and their composites for use in electrochemical sensing, electrocatalysis, and electrochemical energy storage devices (e.g., batteries and supercapacitors), followed by an overview of the remaining challenges and viewpoints for MOF-based materials for these applications.

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“…Copper-based metal–organic frameworks (MOFs) with polycarboxylate linkers have recently attracted attention in the field of electrochemical sensors for the detection of different analytes [ 1 , 2 , 3 , 4 ] due to their potential for increasing electrode/electrolyte interfaces and reducing mass consumption by tuning single atomic metal centers. For example, Cu(BTC) MOF (BTC: trimesic acid) has shown peroxidase-like activity for electrochemical detection of H 2 O 2 [ 5 ] and catechol [ 6 ], respectively.…”

Section: Introductionmentioning

confidence: 99%

Structures, Bonding and Sensor Properties of Some Alkaline o-Phthalatocuprates

et al. 2021

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Comprehensive study of the structure and bonding of disodium, dipotassium and diammonium di-o-phthalatocuprates(II) dihydrates has been undertaken. The crystal structure of ammonium o-phthalatocuprate has been determined. The identity of structures of phthalatocuprate chains in potassium and ammonium salts has been revealed. Vibrational spectra of all three compounds have been recorded, and the assignment of vibrational bands has been made. Force field calculations have shown a minor effect of outer-sphere cations (Na+, K+, NH4+) on both intraligand (C-O) and metal–ligand bond strengths. Synthesized compounds have been tested as electrochemical sensors on D-glucose, dopamine and paracetamol. Their sensitivity to analytes varied in the order of Na+ > K+ > NH4+. This effect has been explained by the more pronounced steric hindrance of copper ions in potassium and ammonium salts.

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A copper-based metal–organic framework/graphene nanocomposite for the sensitive and stable electrochemical detection of DNA bases

Abstract: A simple and easy-operation electrode modification strategy was proposed using Cu-MOF/GO nanohybrids for physiologists and pathologists for the feasible and reliable simultaneous electrochemical detections of DNA bases, namely guanine and adenine.

Cited by 37 publications

References 48 publications

Design of Electrochemically Reduced Graphene Oxide/Titanium Disulfide Nanocomposite Sensor for Selective Determination of Ascorbic Acid

Design of Electrochemically Reduced Graphene Oxide/Titanium Disulfide Nanocomposite Sensor for Selective Determination of Ascorbic Acid

Recent Electrochemical Applications of Metal–Organic Framework-Based Materials

Structures, Bonding and Sensor Properties of Some Alkaline o-Phthalatocuprates

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