A copper(II) complex of a semicarbazone: crystal structure, spectroscopic analysis and cytotoxicity against human cancer cell lines

Gatto, Claudia C.; Miguel, Patrícia Maidana; Almeida, Carolane M.; Santiago, Pedro H. O.; Paier, Carlos Roberto Koscky; Pessoa, Cláudia

doi:10.1007/s11243-017-0154-8

Cited by 8 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It functions as co-factors of various metalloenzymes. Copper in the divalent state is considered as the most stable form and can form different geometries with various ligands such as thiosemicarbazone, semicarbazones, Thiourea and ethylene diammine.. [36,37,38 ]. Due to our interests in the evaluation of biological activities of novel metallic complexes of thiosemicarbazone ligands.…”

Section: Introductionmentioning

confidence: 99%

Anti-cancer activity of novel Schiff base copper (II) complex: synthesis and characterization

Kothari

2023

JOBM

View full text Add to dashboard Cite

A novel thiosemicarbazone substituted schiff base ligand and its Cu(II) complex have been prepared and characterized. Schiff bases are considered as an important pro ligand in coordination chemistry because they easily form stable complexes with biologically active transition metal ions. Such as Cu 2+, Zn2+, Ni2+ etc. In this paper, novel Cu (II) complexes of thiosemicarbazone ligands were synthesised by refluxing thiosemicarbazone substituted pro ligands with copper salts in 1:1 molar ratio in absolute ethanol under thermal condition at 80o c for 5-6 hour. The resulting brown coloured copper complexes were filtered and recrystallized from petroleum ether. In this synthesis, we use absolute ethanol as a polar environment for the synthesis of copper complexes from schiff base ligands because the use of polar solvent medium in synthesis plays a very important role in reducing minimum possibilities of side reactions which hinders the proper conversion of ligands into copper complexes and also reducing the reaction time. All synthesized compounds were characterized through various spectroscopic and pharmacological techniques. FT-IR, UVVis, NMR, Mass, TGA-DTA, XRD spectra techniques were used to confirm the structures of copper complexes and ligands. All compounds are thermal stable up to 350o c. The good results of pharmacological activities of compounds like in-vitro anti -oxidant and anti - cancer activity against DPPH and cisplatin drug, explained the presence of biologically active functional groups are present in ligands as well as their copper complexes. Results found that the copper complexes were more active than the ligands. The synthesis of copper complexes from thiosemicarbazone schiff base ligands in proper stoichiometic ratio is an excellent method of preparing pharmacological active compounds which can be considered as good anti -cancer drug candidate for the treatment of cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Anti-cancer activity of novel Schiff base copper (II) complex: synthesis and characterization

Kothari

2023

JOBM

View full text Add to dashboard Cite

show abstract

“…Recently, a series of copper and nickel complexes of thiosemicarbazones having heterocyclic moiety has been synthesised and found that the nature of heteroatomic ring attached to them can considerably influence the biological activities of these complexes [8] , [9] , [10] , [11] . These ligands and their complexes have been extensively studied exploring their biological properties, including antibacterial, antimalarial, antiviral, antioxidant, cytotoxic and antineoplastic [12] , [13] , [14] , [15] . Besides this, recently the world is in quest for effective drug to treat SARC-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and characterization of novel Ni(II) and Cu(II) complexes as antivirus drug candidates against SARS-CoV-2 and HIV virus

Aprajita

Choudhary

2022

Journal of Molecular Structure

View full text Add to dashboard Cite

“…[ 21–28 ] In previous works, we demonstrated that the coordination of copper(II) to semicarbazone and dithiocarbazate ligands is a strategy to improve the antitumor and antimicrobial activity of the free ligands. [ 29,30 ] For decades, binuclear and polynuclear complexes have attracted significant interest. [ 31–42 ] This interest arises from numerous applications related to different branches of combined natural sciences (physics, chemistry, and biology).…”

Section: Introductionmentioning

confidence: 99%

A binuclear copper(II) complex based on hydrazone ligand: Characterization, molecular docking, and theoretical and antimicrobial investigation

Santiago

Duarte

Nascimento

et al. 2021

Applied Organom Chemis

Self Cite

View full text Add to dashboard Cite

A new binuclear copper(II) complex [Cu 2 L 2 (μ-SO 4 )(dmf)] with the 2-acetylpyridinebenzoylhydrazone (HL) ligand was synthesized and characterized by elemental analysis, Fourier transform infrared (FT-IR), ultravioletvisible (UV-Vis), single-crystal X-ray diffraction, density functional theory (DFT), and molecular docking studies. The crystal structure revealed each copper(II) atom coordinated to the NNO chelating system of the anionic hydrazone ligand and a sulfate bridged. The copper ions are connected by a sulfate bridge, which keeps a distance of 3.292(3) Å between the two copper(II) centers. Additionally, only one of the copper(II) atoms is coordinated to the oxygen atom of the N,N-dimethylformamide (dmf) solvent molecule, resulting in two different geometry to each metal center. CuÁÁÁO interactions are observed for the secondary coordination sphere of Cu1 and Cu2 atoms with distances of 2.545(2) and 2.821(3) Å, respectively. Theoretical studies with DFT were performed to optimize the geometry of the complex and investigate its spectroscopic properties supporting the experimental results. Two different approaches were used in computational calculations, the plane wave using Perdew-Burke-Ernzerhof (PBE) functional and the localized basis set using the following functionals: B3LYP, B3PW91, CAM-B3LYP, LC-wPBE, M06-2X, ωB97-XD, PBE1PBE, and HSEH1PBE. The in vitro antibacterial potential of the new complex was evaluated against pathogenic bacteria and fungi and compared with the free ligand. The molecular docking was used to predict the inhibitory activity of the ligand and complex against one Gram-positive bacteria (Enterococcus faecalis), one Gram-negative bacteria (Enterobacter aerogenes), and one fungi (Candida albicans) species.

show abstract

A copper(II) complex of a semicarbazone: crystal structure, spectroscopic analysis and cytotoxicity against human cancer cell lines

Cited by 8 publications

References 28 publications

Anti-cancer activity of novel Schiff base copper (II) complex: synthesis and characterization

Anti-cancer activity of novel Schiff base copper (II) complex: synthesis and characterization

Design, synthesis and characterization of novel Ni(II) and Cu(II) complexes as antivirus drug candidates against SARS-CoV-2 and HIV virus

A binuclear copper(II) complex based on hydrazone ligand: Characterization, molecular docking, and theoretical and antimicrobial investigation

Contact Info

Product

Resources

About