Natural resources are a boon for human beings, and their conservation for future uses is indispensable. Most importantly, energy-food-water security (EFWS) nexus management is the utmost need of our time. An effective managerial policy for the current distribution and conservation to meet future demand is necessary and challenging. Thus, this paper investigates an interconnected and dynamic EFWS nexus optimization model by considering the socio-economic and environmental objectives with the optimal energy supply, electricity conversion, food production, water resources allocation, and CO2 emissions control in the multi-period time horizons. Due to real-life complexity, various parameters are taken as intuitionistic fuzzy numbers. A novel method called interactive neutrosophic programming approach (INPA) is suggested to solve the EFWS nexus model. To verify and validate the proposed EFWS model, a synthetic computational study is performed. The obtained solution results are compared with other optimization approaches, and the outcomes are also evaluated with significant practical implications. The study reveals that the food production processes require more water resources than electricity production, although recycled water has not been used for food production purposes. The use of a coal-fired plant is not a prominent electricity conversion source. However, natural gas power plants’ service is also optimally executed with a marginal rate of production. Finally, conclusions and future research are addressed. This current study emphasizes how the proposed EFWS nexus model would be reliable and beneficial in real-world applications and help policy-makers identify, modify, and implement the optimal EFWS nexus policy and strategies for the future conservation of these resources.