A Core Outcome Set for Evaluation of Interventions to Prevent Preterm Birth

Hooft, Janneke van ’t; Duffy, James M N; Daly, Mandy; Williamson, Paula; Meher, Shireen; Thom, Elizabeth; Saade, George R.; Alfirević, Z̄arko; Mol, Ben Willem J.; Khan, Khalid S.

doi:10.1097/aog.0000000000001195

Cited by 179 publications

(168 citation statements)

References 16 publications

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“…Three reviews clearly described their search strategy, two searched multiple bibliographical databases (range 3–4) and a single review limited their search to the Cochrane Pregnancy and Childbirth Group's Specialised Register. All reviews applied a date restriction and two described the rationale for this: Van ‘t Hooft et al . included randomised trials published after the first Consolidated Standards of Reporting Trials (CONSORT) statement and Potter et al .…”

Section: Resultsmentioning

confidence: 99%

Core outcome sets in women's and newborn health: a systematic review

Duffy

Rolph

Gale

et al. 2017

BJOG

142

165

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Section: Resultsmentioning

confidence: 99%

Core outcome sets in women's and newborn health: a systematic review

Duffy

Rolph

Gale

et al. 2017

BJOG

142

165

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“…The Delphi consensus methodology uses expert opinion to address questions for which empirical data are unavailable or inadequate (23). Recently, the Delphi method has been used to develop COS for research on conditions as diverse as multiple sclerosis (24), stroke (25), and preterm birth (26). More information about Delphi methodology, identifying outcome domains, and survey development is available in Table E1.…”

Section: Methodsmentioning

confidence: 99%

Core Domains for Clinical Research in Acute Respiratory Failure Survivors: An International Modified Delphi Consensus Study

Turnbull¹,

Sepúlveda

Dinglas

et al. 2017

Critical Care Medicine

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Objectives To identify the core “domains” (i.e., patient outcomes, health-related conditions, or aspects of health) that relevant stakeholders agree are essential to assess in all clinical research studies evaluating the outcomes of acute respiratory failure survivors after hospital discharge. Design A two-round consensus process, using a modified Delphi methodology, with participants from 16 countries, including patient and caregiver representatives. Prior to voting, participants were asked to review: 1) results from surveys of clinical researchers, acute respiratory failure survivors, and caregivers, that rated the importance of 19 preliminary outcome domains, and 2) results from a qualitative study of acute respiratory failure survivors’ outcomes after hospital discharge, as related to the 19 preliminary outcome domains. Participants also were asked to suggest any additional potential domains for evaluation in the first Delphi survey. Setting Web-based surveys of participants representing 4 stakeholder groups relevant to clinical research evaluating post-discharge outcomes of acute respiratory failure survivors: clinical researchers, clinicians, patients and caregivers, and US federal research funding organizations. Interventions None. Measurements and Main Results Survey response rates were 97% and 99% in Round 1 and Round 2 respectively. There were 7 domains that met the a priori consensus criteria to be designated as core domains: physical function, cognition, mental health, survival, pulmonary function, pain, and muscle and/or nerve function. Conclusion This study generated a consensus-based list of core domains that should be assessed in all clinical research studies evaluating acute respiratory failure survivors after hospital discharge. Identifying appropriate measurement instruments to assess these core domains is an important next step toward developing a set of core outcome measures for this field of research.

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“…The GoNet (Global Obstetrics Network) initiative was founded by international investigators to standardize outcomes for PTB studies. A core outcome set is developed with an international multidisciplinary perspective to ensure that data from PTB trials can be compared and combined 107. This combination and pooling of data can be used in the performance of an individual participant data meta-analysis 108.…”

Section: Future Prospectsmentioning

confidence: 99%

Prevention of preterm delivery: current challenges and future prospects

Zijl

Koullali

Mol

et al. 2016

IJWH

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Preterm birth (PTB), defined as delivery at <37 weeks of gestation, is the most important cause of neonatal morbidity and mortality. Therefore, preventing PTB is one of the main goals in obstetric care. In this review, we provide an overview of the current available literature on screening for risk factors for PTB and a summary of preventive strategies in both low-risk and high-risk women with singleton or multiple gestations. Furthermore, current challenges and future prospects on PTB are discussed. For an optimal prevention of PTB, risk stratification should be based on a combination of (maternal) risk factors, obstetric history, and screening tools. Cervical length measurements can help identify women at risk. Thereafter, preventive strategies such as progesterone, pessaries, and cerclage may help prevent PTB. Effective screening and prevention of PTB vary between the different pregnancy populations. In singleton or multiple pregnancies with a short cervix, without previous PTB, a pessary or progesterone might prevent PTB. In women with a (recurrent) PTB in the past, progesterone and a cerclage may prevent recurrence. The effect of a pessary in these high-risk women is currently being studied. A strong collaboration between doctors, patients’ organizations, pharmaceutical companies, and (international) governments is needed to reduce the morbidity and mortality as a result of spontaneous PTB.

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A Core Outcome Set for Evaluation of Interventions to Prevent Preterm Birth

Abstract: COMET Initiative, http://www.comet-initiative.org/studies/details/603, REGISTRATION NUMBER: 603.

Cited by 179 publications

References 16 publications

Core outcome sets in women's and newborn health: a systematic review

Core outcome sets in women's and newborn health: a systematic review

Core Domains for Clinical Research in Acute Respiratory Failure Survivors: An International Modified Delphi Consensus Study

Prevention of preterm delivery: current challenges and future prospects

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