A core-satellite micellar system against primary tumors and their lymphatic metastasis through modulation of fatty acid metabolism blockade and tumor-associated macrophages

He, Xuan; Deng, Tao; Guo, Rong; Wang, Yashi; Li, Ting; Zang, Shuya; Li, Jiaxin; Zhang, Ling; Li, Man; He, Qin

doi:10.1039/d2nr04693h

Cited by 5 publications

(3 citation statements)

References 62 publications

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“…This finding aligns with in vitro data, which suggest that the content of oxidized lipids in the tumor cell membrane is associated with their metastatic potential [70]. These lipids play a crucial role in the processes that support the survival of tumor cells [71,72]. Conversely, sphingomyelins exhibit the opposite trend.…”

Section: Discussionsupporting

confidence: 89%

Integrating Proteomics and Lipidomics for Evaluating the Risk of Breast Cancer Progression: A Pilot Study

et al. 2023

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Metastasis is a serious and often life-threatening condition, representing the leading cause of death among women with breast cancer (BC). Although the current clinical classification of BC is well-established, the addition of minimally invasive laboratory tests based on peripheral blood biomarkers that reflect pathological changes in the body is of utmost importance. In the current study, the serum proteome and lipidome profiles for 50 BC patients with (25) and without (25) metastasis were studied. Targeted proteomic analysis for concertation measurements of 125 proteins in the serum was performed via liquid chromatography–multiple reaction monitoring mass spectrometry (LC–MRM MS) using the BAK 125 kit (MRM Proteomics Inc., Victoria, BC, Canada). Untargeted label-free lipidomic analysis was performed using liquid chromatography coupled to tandem mass-spectrometry (LC–MS/MS), in both positive and negative ion modes. Finally, 87 serum proteins and 295 lipids were quantified and showed a moderate correlation with tumor grade, histological and biological subtypes, and the number of lymph node metastases. Two highly accurate classifiers that enabled distinguishing between metastatic and non-metastatic BC were developed based on proteomic (accuracy 90%) and lipidomic (accuracy 80%) features. The best classifier (91% sensitivity, 89% specificity, AUC = 0.92) for BC metastasis diagnostics was based on logistic regression and the serum levels of 11 proteins: alpha-2-macroglobulin, coagulation factor XII, adiponectin, leucine-rich alpha-2-glycoprotein, alpha-2-HS-glycoprotein, Ig mu chain C region, apolipoprotein C-IV, carbonic anhydrase 1, apolipoprotein A-II, apolipoprotein C-II and alpha-1-acid glycoprotein 1.

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Section: Discussionsupporting

confidence: 89%

Integrating Proteomics and Lipidomics for Evaluating the Risk of Breast Cancer Progression: A Pilot Study

et al. 2023

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“…(Figure S1) 1 H NMR characterization of the preparation of Au@Gd-SiO 2 -HA-LyP-1, (Figure S2) characterization of the stability of Au@Gd-SiO 2 -HA-LyP-1 NPs, (Figure S3) XPS characteristic spectra of Au@Gd-SiO 2 -HA-Lyp-1 NPs, (Figure S4) construction of a lung orthotopic tumor lymphatic metastasis model, and (Figure S5) images of tumor treatment surgery guided by MRI (PDF)…”

Section: * Sı Supporting Informationmentioning

confidence: 99%

“…Lymphatic metastasis is the process by which tumor cells migrate from the primary tumor site through the lymphatic system to other areas. 1 This type of metastasis typically signifies an advanced stage of the tumor, thereby intensifying the challenges and intricacies associated with treatment. 2 The presence of lymphatic metastasis is strongly correlated with patient survival rates.…”

Section: ■ Introductionmentioning

confidence: 99%

Multifunctional Nanoprobe Au@Gd-SiO₂-HA-Lyp-1/DOX with Dual-Targeting Functions Derived from HA and LyP-1: Diagnostic and Therapeutic Potential for Tumor Lymphatic Metastasis

Chen,

Wan,

Zhu

et al. 2024

Biomacromolecules

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LyP-1 nanoprobe, assessing its diagnostic and therapeutic capabilities. This nanoprobe integrates a Au core with a Gd-SiO 2 shell and dual-targeting HA-LyP-1 molecules. We evaluated its size, shape, and functional properties using various characterization techniques, alongside in vivo and in vitro toxicity tests. The spherical nanoprobes have a 50 nm diameter and contain 1.37% Gd. They specifically target lymphatic metastasis sites and tumor cells, showing enhanced MRI contrast and effective, targeted DOX delivery with reduced normal tissue toxicity. The Au@Gd-SiO 2 -HA-LyP-1 nanoprobe is a promising tool for diagnosing and treating lung cancer lymphatic metastasis, featuring dual-targeting and superior imaging capabilities.

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Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy

Zhang,

Li,

Huang

et al. 2024

Acta Pharmaceutica Sinica B

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A core-satellite micellar system against primary tumors and their lymphatic metastasis through modulation of fatty acid metabolism blockade and tumor-associated macrophages

Abstract: Lymph nodes (LNs) are the initial sanctuary of various metastatic tumor cells, thus precise lymphatic drug delivery strategy is necessary for effective inhibition of metastasis. However, the complex biological barriers...

Cited by 5 publications

References 62 publications

Integrating Proteomics and Lipidomics for Evaluating the Risk of Breast Cancer Progression: A Pilot Study

Integrating Proteomics and Lipidomics for Evaluating the Risk of Breast Cancer Progression: A Pilot Study

Multifunctional Nanoprobe Au@Gd-SiO₂-HA-Lyp-1/DOX with Dual-Targeting Functions Derived from HA and LyP-1: Diagnostic and Therapeutic Potential for Tumor Lymphatic Metastasis

Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy

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A core-satellite micellar system against primary tumors and their lymphatic metastasis through modulation of fatty acid metabolism blockade and tumor-associated macrophages

Abstract: Lymph nodes (LNs) are the initial sanctuary of various metastatic tumor cells, thus precise lymphatic drug delivery strategy is necessary for effective inhibition of metastasis. However, the complex biological barriers...

Cited by 5 publications

References 62 publications

Integrating Proteomics and Lipidomics for Evaluating the Risk of Breast Cancer Progression: A Pilot Study

Integrating Proteomics and Lipidomics for Evaluating the Risk of Breast Cancer Progression: A Pilot Study

Multifunctional Nanoprobe Au@Gd-SiO2-HA-Lyp-1/DOX with Dual-Targeting Functions Derived from HA and LyP-1: Diagnostic and Therapeutic Potential for Tumor Lymphatic Metastasis

Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy

Contact Info

Product

Resources

About

Multifunctional Nanoprobe Au@Gd-SiO₂-HA-Lyp-1/DOX with Dual-Targeting Functions Derived from HA and LyP-1: Diagnostic and Therapeutic Potential for Tumor Lymphatic Metastasis