In the past two decades, paleogenetics has made a significant impact on the field of archaeology. Interestingly, paleogenetic methods have not been extensively employed in osteoarchaeology despite its ability to address issues that cannot be resolved through traditional osteological analysis alone. This paper tackles a problem concerning the relationship between human remains in a commingled deposit from Midnight Terror Cave, Belize. Paleogenetics demonstrates that the bones in question belonged to multiple individuals, thus resolving an issue that was at the heart of the interpretation of social processes at the site. Copyright © 2016 John Wiley & Sons, Ltd.