A Correlation Between Intracellular Zinc Content and Osteosarcoma

Meshkini, Azadeh

doi:10.1007/s12011-020-02466-4

Cited by 8 publications

(7 citation statements)

References 96 publications

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“…However, when we evaluate the relationship with living organisms, it can easily be noticed that zinc is the second most abundant transition ion in the series of essential elements, indispensable for a huge number of biological processes. This trace element is critical for cell growth, genomic stability, signal transcription factors, and for the structure and function of a wide range of cellular proteins [ 1 , 2 , 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Zinc(II) Carboxylate Coordination Polymers with Versatile Applications

et al. 2023

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This review considers the applications of Zn(II) carboxylate-based coordination polymers (Zn-CBCPs), such as sensors, catalysts, species with potential in infections and cancers treatment, as well as storage and drug-carrier materials. The nature of organic luminophores, especially both the rigid carboxylate and the ancillary N-donor bridging ligand, together with the alignment in Zn-CBCPs and their intermolecular interaction modulate the luminescence properties and allow the sensing of a variety of inorganic and organic pollutants. The ability of Zn(II) to act as a good Lewis acid allowed the involvement of Zn-CBCPs either in dye elimination from wastewater through photocatalysis or in pathogenic microorganism or tumor inhibition. In addition, the pores developed inside of the network provided the possibility for some species to store gaseous or liquid molecules, as well as to deliver some drugs for improved treatment.

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Section: Introductionmentioning

confidence: 99%

Zinc(II) Carboxylate Coordination Polymers with Versatile Applications

et al. 2023

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“…Serum levels of Zn are decreased in several cancers (29). Zn has tumor suppressing activities and its levels are decreased in several solid tumor cancers, including prostate (30, 31), bladder (32), liver (33), bone (34) and head and neck(35). However, in breast cancer, Zn contributes to cancer progression (36).…”

Section: Discussionmentioning

confidence: 99%

MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells

Verma

Aggarwal

Reigle

et al. 2022

Preprint

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MAP1LC3C (LC3C) is a member of the microtubule associated family of proteins that are essential in the formation of autophagosomes and lysosomal degradation of cargo. LC3C has tumor suppressing activity and its expression is dependent on kidney cancer tumor suppressors, such as VHL and FLCN. Recently we demonstrated that LC3C autophagy is regulated by noncannonical upstream regulatory complexes and targets for degradation postdivision midbody rings associated with cancer cells stemness. Here we show that loss of LC3C leads to peripheral positioning of the lysosomes and lysosomal exocytosis (LE) in a subset of cells. This process is independent of the autophagic activity of LC3C. Analysis of isogenic cells with low and high LE shows substantial transcriptomic reprogramming with altered expression of Zn-related genes and activity of Polycomb Repressor Complex 2 (PRC2), accompanied by a robust decrease in intracellular Zn. Metabolomic analysis revealed alterations in amino acid steady-state levels. Cells with augmented LE show tumor initiation properties and form aggressive tumors in xenograft models. Immunocytochemistry identified high levels of LAMP1 on the plasma membrane of cancer cells in human ccRCC and reduced levels of Zn, an indication that LE is a frequent event in ccRCC, potentially contributing to the loss of Zn. Overall, these data indicate that an important tumor suppressing activity of LC3C is contributing to the reprogramming of lysosomal activity and Zn metabolism with implication for epigenetic remodeling in a subpopulation of tumor propagating properties of cancer cells.

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“…The ZIP and ZnT families act as importers and exporters of zinc, respectively [332]. Although the total intracellular zinc concentration is in the range of 100 to 500 Mm, 90% of total zinc is tightly bound to proteins, where it acts as a cofactor for approximately 300 enzymes and hormones [333], while free zinc ion (within the range of 10-100 pM) acts as a second messenger for numerous signaling pathways [334].…”

Section: Seleniummentioning

confidence: 99%

“…Cells 2021, 10, x 28 of 61 bound to proteins, where it acts as a cofactor for approximately 300 enzymes and hormones [333], while free zinc ion (within the range of 10-100 pM) acts as a second messenger for numerous signaling pathways [334]. Overall, zinc is dynamically stored between the mineral and cellular components of the bone, and therefore it is released from the reservoir during the breakdown of the skeleton, whereas it is incorporated during bone formation.…”

Section: Seleniummentioning

confidence: 99%

Effects of Extracellular Osteoanabolic Agents on the Endogenous Response of Osteoblastic Cells

Alloisio

Ciaccio

Fasciglione

et al. 2021

Cells

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The complex multidimensional skeletal organization can adapt its structure in accordance with external contexts, demonstrating excellent self-renewal capacity. Thus, optimal extracellular environmental properties are critical for bone regeneration and inextricably linked to the mechanical and biological states of bone. It is interesting to note that the microstructure of bone depends not only on genetic determinants (which control the bone remodeling loop through autocrine and paracrine signals) but also, more importantly, on the continuous response of cells to external mechanical cues. In particular, bone cells sense mechanical signals such as shear, tensile, loading and vibration, and once activated, they react by regulating bone anabolism. Although several specific surrounding conditions needed for osteoblast cells to specifically augment bone formation have been empirically discovered, most of the underlying biomechanical cellular processes underneath remain largely unknown. Nevertheless, exogenous stimuli of endogenous osteogenesis can be applied to promote the mineral apposition rate, bone formation, bone mass and bone strength, as well as expediting fracture repair and bone regeneration. The following review summarizes the latest studies related to the proliferation and differentiation of osteoblastic cells, enhanced by mechanical forces or supplemental signaling factors (such as trace metals, nutraceuticals, vitamins and exosomes), providing a thorough overview of the exogenous osteogenic agents which can be exploited to modulate and influence the mechanically induced anabolism of bone. Furthermore, this review aims to discuss the emerging role of extracellular stimuli in skeletal metabolism as well as their potential roles and provide new perspectives for the treatment of bone disorders.

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A Correlation Between Intracellular Zinc Content and Osteosarcoma

Cited by 8 publications

References 96 publications

Zinc(II) Carboxylate Coordination Polymers with Versatile Applications

Zinc(II) Carboxylate Coordination Polymers with Versatile Applications

MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells

Effects of Extracellular Osteoanabolic Agents on the Endogenous Response of Osteoblastic Cells

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