Heating, ventilating and air-conditioning (HVAC) systems are typical non-linear time-variable multivariate systems with disturbances and uncertainties. In this paper, an approach based on a combined neuro-fuzzy model for dynamic and automatic regulation of indoor temperature is proposed. The proposed artificial neural network performs indoor temperatures forecasts that are used to feed a fuzzy logic control unit in order to manage the on/off switching of the HVAC system and the regulation of the inlet air speed. Moreover, the used neural network is optimized by the analytical calculation of the embedding parameters, and the goodness of this approach is tested through MATLAB. The fuzzy controller is driven by the indoor temperature forecasted by the neural network module and is able to adjust the membership functions dynamically, since thermal comfort is a very subjective factor and may vary even in the same subject. The paper shows some experimental results, through a real implementation in an embedded prototyping board, of the proposed approach in terms of the evolution of the inlet air speed injected by the fan coils, the indoor air temperature forecasted by the neural network model and the adjusting of the membership functions after receiving user feedback.