2020
DOI: 10.1101/2020.09.15.299172
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A cortical circuit mechanism for coding and updating task structural knowledge in inference-based decision-making

Abstract: Making decisions based on knowledge about causal environmental structures is a hallmark of higher cognition in mammalian brains. Despite mounting work in psychological and cognitive sciences, how the brain implements knowledge-based decision-making at neuronal circuit level remains a terra incognita. Here we established an inference-based auditory categorization task, where mice performed within-session re-categorization of stimuli by inferring the changing task rules. Using a belief-state reinforcement learni… Show more

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Cited by 2 publications
(1 citation statement)
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“…Crucially, our findings indicate that downstream circuits do not necessarily need to continuously compute reward distributions based on stimulus-outcome associations because this information can be efficiently embedded in the neural codes of early sensory systems. This notion is supported by a recent study showing that functional remapping of stimulus-reward contingencies in early sensory areas causally depends on top-down control signals from prefrontal structures (23,24,33). We argue that this gives the organism the advantage of rapidly transmitting behaviorally-relevant information encoded by early sensory systems to downstream circuits specialized in action, learning, or decision-making.…”
Section: Discussionsupporting
confidence: 63%
“…Crucially, our findings indicate that downstream circuits do not necessarily need to continuously compute reward distributions based on stimulus-outcome associations because this information can be efficiently embedded in the neural codes of early sensory systems. This notion is supported by a recent study showing that functional remapping of stimulus-reward contingencies in early sensory areas causally depends on top-down control signals from prefrontal structures (23,24,33). We argue that this gives the organism the advantage of rapidly transmitting behaviorally-relevant information encoded by early sensory systems to downstream circuits specialized in action, learning, or decision-making.…”
Section: Discussionsupporting
confidence: 63%