A cost-comparative analysis of intravenous Ferric Carboxymaltose versus Iron Sucrose for the ambulatory treatment of Iron-deficiency Anemia in a major tertiary care hospital in Saudi Arabia

Alzahrani, S; Almeziny, M; Narang, A; Mohamed, O; Almeziny, Salem; Almeziny, Abdullah

doi:10.61466/ijcmr1010005

Cited by 1 publication

(2 citation statements)

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“…Clinical manifestations, CSF haemorrhage resulting in a sterile inflammation, and CSF analysis results coincide with the underlying condition 3 . Furthermore, sedative medication used in conjunction with the underlying condition's low state of consciousness can disguise indicators of a central nervous system infection 43,44 . As a result, considerable clinical suspicion is required.…”

Section: Certain Infectionsmentioning

confidence: 99%

“…3 Furthermore, sedative medication used in conjunction with the underlying condition's low state of consciousness can disguise indicators of a central nervous system infection. 43,44 As a result, considerable clinical suspicion is required. Surprisingly, meningitis only manifested in 23% of individuals within 10 days following the removal of EVD.…”

Section: Infections Related To Ventriculoperitoneal and Ventriculoatr...mentioning

confidence: 99%

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Treatment of wound infections linked to neurosurgical implants

Wang,

Wang

et al. 2023

International Wound Journal

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As neurosurgery has advanced technologically, more and more neurosurgical implants are being employed on an aging patient population with several comorbidities. As a result, there is a steady increase in the frequency of infections linked to neurosurgical implants, which causes serious morbidity and mortality as well as abnormalities of the skull and inadequate brain protection. We discuss infections linked to internal and external ventricular and lumbar cerebrospinal fluid drainages, neurostimulators, craniotomies, and cranioplasty in this article. Biofilms, which are challenging to remove, are involved in all implant‐associated illnesses. It takes a small quantity of microorganisms to create a biofilm on the implant surface. Skin flora bacteria are implicated in the majority of illnesses. Microorganisms that cause disruptions in wound healing make their way to the implant either during or right after surgery. In about two thirds of patients, implant‐associated infections manifest early (within the first month after surgery), whereas the remaining infections present later as a result of low‐grade infections or by direct extension from adjacent infections (per continuitatem) to the implants due to soft tissue damage. Except for ventriculo‐atrial cerebrospinal fluid shunts, neurosurgical implants are rarely infected by the haematogenous route. This research examines established and clinically validated principles that are applicable to a range of surgical specialties using implants to treat biofilm‐associated infections in orthopaedic and trauma cases. Nevertheless, there is little evidence and no evaluation in sizable patient populations to support the success of this extrapolation to neurosurgical patients. An optimal microbiological diagnostic, which includes sonicating removed implants and extending culture incubation times, is necessary for a positive result. Additionally, a strategy combining surgical and antibiotic therapy is needed. Surgical procedures involve a suitable debridement along with implant replacement or exchange, contingent on the biofilm's age and the state of the soft tissue. A protracted biofilm‐active therapy is a component of antimicrobial treatment, usually lasting 4–12 weeks. This idea is appealing because it allows implants to be changed or kept in place for a single surgical procedure in a subset of patients. This not only enhances quality of life but also lowers morbidity because each additional neurosurgical procedure increases the risk of secondary complications like intracerebral bleeding or ischemia.

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Section: Certain Infectionsmentioning

confidence: 99%