A cost-effectiveness analysis of a hydration response technology dressing in the treatment of venous leg ulcers in the UK

Walzer, Stefan; Dröschel, Daniel; Vollmer, L; Atkin, Leanne; Ousey, Karen

doi:10.12968/jowc.2018.27.3.166

Cited by 14 publications

(23 citation statements)

References 19 publications

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“…The most common intervention type across the studies was dressings for VLUs, the subject of 11 studies (48%) [24][25][26][27][28][29][30][31][32][33][34]. There were also four studies each focusing on compression bandaging [35][36][37][38] and extracellular matrices [39][40][41][42].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Ten of the studies (43%) were published in the Journal of Wound Care [24-27, 35-37, 39, 43, 45], with no other journal responsible for more than one paper. There were 11 cost effectiveness analyses (CEAs) [26, 28-33, 35, 40-42] and three cost utility analyses (CUAs) [25,36,38], with the remaining nine studies a combination of both CEA and CUA [24,27,34,37,39,[43][44][45][46]. For the CEAs, the most common clinical outcome related to percentage of patients healed (12 outcomes) [26,27,30,32,33,37,39,[41][42][43][44][45], with time taken for the ulcer to heal used as an outcome in ten studies [24, 25, 29, 31, 34-36, 41, 42, 46], and reduction in wound area size used twice [28,29].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…This paper used standard gamble methodology on a sample of 200 participants, including both the general population and VLU patients, to allow for utilities to be assigned to different VLU states [44]. The remaining three QALY measurements obtained utility values from randomised controlled trials that used the EuroQol 5D and/or Short Form 6D questionnaires [24,38,46].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Markov models were the most common decision-analytical approach, being used in 12 (52%) studies [24,28,29,34,35,38,39,[41][42][43][44]46]. The most common time cycle length used for these models was 1 week with a 1-year time horizon, found in five studies [24,34,35,41,46]. Other time horizons varied greatly, from 14 days [28] to 12 years [38].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The Markov models used in the included studies often had a simplistic structure. Commonly, the following states were used, 'healed', 'unhealed' and 'dead' [38,41,46], whilst some studies included more detailed states such as 'improved', 'worsened' and 'complications' [24,44]. The cycle lengths used in the Markov models ranged from 1 day to 1 month, with this length mostly determined by the frequency of outpatient appointments.…”

Section: Model Structurementioning

confidence: 99%

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A Systematic Review of Model-Based Economic Evaluations of Treatments for Venous Leg Ulcers

Layer

McManus

Levell

2019

PharmacoEconomics Open

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Objective The aim of this review was to identify, and assess the quality of, published model-based economic evaluations relating to treatments for patients with venous leg ulcers to help inform future decision-analytic models in this clinical area. Methods A systematic literature search was performed on six electronic databases, from database inception until 21 May 2018. Search results were screened against predefined criteria by two independent reviewers. Data was then extracted from the included studies using a standardised form, whilst the decision-analytic model-specific Philips Checklist was used to assess quality and to inform model critique. Results A total of 23 models were identified, 12 studies used a Markov modelling approach, five used decision trees and six studies did not detail the model type. Studies were predominantly from the National Health Service (NHS)/payer perspective, with only two taking a societal perspective. Interventions were wide ranging, but dressing technologies (11/23) were most common. The intervention studied was found to be dominant in 22/23 studies. The reporting quality of papers was mostly low, with evidence behind model structures, time horizons and data selection consistently underreported across the included papers. Conclusions This review has identified a sizeable literature of model-based economic evaluations, evaluating treatments for venous leg ulcers. However, the methods used to conduct such studies were generally poorly reported. In particular, the reporting of evidence surrounding the model structure, justification of the time horizon used and the rationale for selecting data inputs should be focused on in any future models developed.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Model Structurementioning

confidence: 99%

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A Systematic Review of Model-Based Economic Evaluations of Treatments for Venous Leg Ulcers

Layer

McManus

Levell

2019

PharmacoEconomics Open

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Superabsorbent wound dressings versus foams dressings for the management of moderate-to-highly exuding venous leg ulcers in French settings: An early stage model-based economic evaluation

Veličković

Prieto

Krga

et al. 2022

Journal of Tissue Viability

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An Early-Stage Economic Evaluation of Superabsorbent Wound Dressings for the Management of Moderately to Highly Exuding Leg Ulcers in Slovakian Settings

Veličković,

Serafin,

Arlouskaya

et al. 2024

Adv Skin Wound Care

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BACKGROUND The management of chronic leg ulcers, including venous leg ulcers (VLUs), causes a considerable economic and clinical burden to healthcare systems. Factors such as nursing time, hospital care, and wound dressings account for approximately 85% of the total cost. Superabsorbent dressings (eg, superabsorbent polymers [SAPs]) are recommended as a first-line treatment for moderately to highly exuding VLUs. OBJECTIVE To assess the cost-effectiveness of utilizing SAPs compared with the standard of care (SoC) for managing patients with moderately to highly exuding VLUs within the Slovakia healthcare settings. METHODS The decision-analytic modeling method used a Markov process as microsimulation, with a time horizon of 6 months, from the perspective of the third-party payer in Slovakia. All model inputs were based on data identified through systematic literature reviews. RESULTS According to model predictions, the use of SAPs instead of SoC in patients with moderately to highly exuding leg ulcers in Slovakian settings would lead to an improved healing rate of 2.2%, incremental health-related quality of life of 0.143 quality-adjusted life-weeks, and total direct cost savings of €75 (USD $82) per patient over a 6-month period. CONCLUSIONS The evaluation’s results align with clinical recommendations that endorse superabsorbent wound dressings as the preferred first-line treatment for moderately to highly exuding VLUs. The findings support the use of these dressings as a cost-saving solution for the National Insurance in Slovakia, when compared with SoC.

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A cost-effectiveness analysis of a hydration response technology dressing in the treatment of venous leg ulcers in the UK

Abstract: Clinical benefits and cost savings increase when real-life practice assumptions, based on expert opinion, are included. Based on the underlying health economic model, HRDT is more effective and less costly than other comparative products in VLUs in the UK.

Cited by 14 publications

References 19 publications

A Systematic Review of Model-Based Economic Evaluations of Treatments for Venous Leg Ulcers

A Systematic Review of Model-Based Economic Evaluations of Treatments for Venous Leg Ulcers

Superabsorbent wound dressings versus foams dressings for the management of moderate-to-highly exuding venous leg ulcers in French settings: An early stage model-based economic evaluation

An Early-Stage Economic Evaluation of Superabsorbent Wound Dressings for the Management of Moderately to Highly Exuding Leg Ulcers in Slovakian Settings

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