Entropic dynamics (ED) are a general framework for constructing indeterministic dynamical models based on entropic methods. ED have been used to derive or reconstruct both non-relativistic quantum mechanics and quantum field theory in curved space-time. Here we propose a model for a quantum scalar field propagating in dynamical space-time. The approach rests on a few key ingredients: (1) Rather than modelling the dynamics of the fields, ED models the dynamics of their probabilities. (2) In accordance with the standard entropic methods of inference, the dynamics are dictated by information encoded in constraints. (3) The choice of the physically relevant constraints is dictated by principles of symmetry and invariance. The first of such principle imposes the preservation of a symplectic structure which leads to a Hamiltonian formalism with its attendant Poisson brackets and action principle. The second symmetry principle is foliation invariance, which, following earlier work by Hojman, Kuchař, and Teitelboim, is implemented as a requirement of path independence. The result is a hybrid ED model that approaches quantum field theory in one limit and classical general relativity in another, but is not fully described by either. A particularly significant prediction of this ED model is that the coupling of quantum fields to gravity implies violations of the quantum superposition principle.