A Creutzfeldt‐Jakob disease case misdiagnosed with acute cerebral infarction and review of the literature

Xu, Zhouwei; Zhao, Yuwu

doi:10.1002/ccr3.3388

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Prion disease causes rapid cognitive decline, movement disorders, and visual deficit [4]. Patients of this disease will be in danger of increasing in aging and die within a year [5]. Therefore, early diagnosis is very important.…”

Section: Introductionmentioning

confidence: 99%

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Functional Connectivity and Small-World Networks in Prion Disease

TAKEOKA

Yamazaki

Kuroiwa

et al. 2023

IEICE Trans. Inf. & Syst.

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Section: Introductionmentioning

confidence: 99%

“…Diagnosis of prion disease are made by many kinds of biomarkers [6]. However, clinical diagnosis is not always accurate and is increasingly misdiagnosed [5], [7].…”

Section: Introductionmentioning

confidence: 99%

Functional Connectivity and Small-World Networks in Prion Disease

TAKEOKA

Yamazaki

Kuroiwa

et al. 2023

IEICE Trans. Inf. & Syst.

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“…The condition has a poor prognosis, with a life expectancy ranging from a few weeks to a year. Furthermore, there is no specific medication available to decrease the disease’s progression [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Misdiagnosis of rarest subtype of sporadic Creutzfeldt Jakob Disease: a case report

et al. 2023

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Background Creutzfeldt–Jakob disease (CJD), is a deadly degenerative condition of the central nervous system marked by rapidly progressive dementia. Magnetic resonance imaging (MRI) abnormalities in the cerebral cortex, basal ganglia, thalamus, and cerebellum could indicate severe acute diseases caused by a variety of factors. Although their MRI patterns may resemble those of CJD, clinical history, additional MRI findings, and laboratory testing are all necessary to provide a reliable difference. Here, we report a misdiagnosed case of probable VV1 subtype of sporadic CJD (sCJD) in which follow-up MRI supported the diagnosis. Case presentation A 41-year-old male patient attended the Neuropsychiatry Department with rapidly progressive dementia, akinetic mutism, and difficulty walking and speaking. His problem began with forgetfulness, disorganized behavior, and disorganized speech 7 months earlier which progressed rapidly and was accompanied by aphasia, apraxia, agnosia, and akinetic mutism in the last 2 months. On neurologic examination, hypertonia, hyperreflexia, frontal ataxia, bradykinesia, gait apraxia, and aphasia were noted. Based on clinical features and rapid symptoms progression the likely diagnosis of CJD was suspected. MRI and electroencephalography (EEG) were advised. MRI revealed features of diffuse cortical injury of both cerebral hemispheres also involving bilateral corpus striatum with evidence of cerebral volume loss. EEG showed lateralized periodic theta slow waves on the right side. According to the CDC’s diagnostic criteria for CJD, the diagnosis of probable sCJD was established. Supportive care and symptomatic treatment are provided for the patient. After a 1-month follow up the patient’s condition deteriorated significantly. The time-lapse from the first reported symptom to death was about 13 months. Conclusion The need of addressing CJD in patients presenting with rapidly progressive dementia is highlighted in this case report. In the early stages of the disease, interpretation of MRI results might cause diagnostic difficulties; therefore, follow-up MRI is critical in obtaining the correct diagnosis.

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Parkinsonism as an initial presentation of Creutzfeldt‐Jakob disease: A case report and review of literature

Bahrami,

Karimi,

Khosravi

et al. 2024

Clinical Case Reports

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Key Clinical MessageCreutzfeldt‐Jakob disease (CJD) is a rapidly progressive, fatal neurodegenerative disorder. This case highlights parkinsonism as a rare initial manifestation of sporadic CJD (sCJD), emphasizing the need for heightened clinical awareness to prevent misdiagnosis. Early and accurate diagnosis of sCJD is crucial for preventing potential iatrogenic transmission and optimizing patient management.AbstractCreutzfeldt‐Jakob disease (CJD) is a fatal neurodegenerative illness. While movement disorders may be present at the onset of the disease in about half of those with sporadic CJD (sCJD), parkinsonism is a rare initial presentation. In this article, we report a case of CJD with parkinsonism as the initial presentation of the disease. We report a 69‐year‐old lady with initial symptoms of gait difficulty, tremor, and bradykinesia. Later, she developed cognitive impairment, ataxia, chin tremor, and myoclonic jerks. Her condition worsened to the point of akinetic mutism. She was diagnosed with probable sCJD after detecting protein 14‐3‐3 in her cerebrospinal fluid and observing typical imaging features.This case report illustrates important aspects of an inevitably fatal and rapidly progressing disease's early presentation and clinical features. The uncommon initial presentations of sCJD should be considered with the intent of preventing misdiagnosis in the future. Early diagnosis of sCJD can prevent possible iatrogenic disease transmission and improve patient care.

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A Creutzfeldt‐Jakob disease case misdiagnosed with acute cerebral infarction and review of the literature

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 4 publications

References 17 publications

Functional Connectivity and Small-World Networks in Prion Disease

Functional Connectivity and Small-World Networks in Prion Disease

Misdiagnosis of rarest subtype of sporadic Creutzfeldt Jakob Disease: a case report

Parkinsonism as an initial presentation of Creutzfeldt‐Jakob disease: A case report and review of literature

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