A critical analysis of the management of pregnancy in diabetic women

McLendon, Harold; Bottomy, John R.

doi:10.1016/0002-9378(60)90572-x

Cited by 12 publications

(3 citation statements)

References 7 publications

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“…The classification of diabetes according to severity as proposed by White (1959) has not been emphasized, however, because of certain recognized pitfalls as stressed by McLendon and Bottomy (1960). The classification of diabetes according to severity as proposed by White (1959) has not been emphasized, however, because of certain recognized pitfalls as stressed by McLendon and Bottomy (1960).…”

Section: %mentioning

confidence: 99%

Oestriol Excretion in the Pregnancy Complicated by Diabetes Mellitus

Evans

Taft

Rome

et al. 1972

Aust NZ J Obst Gynaeco

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Urinary oestriol excretion was studied throughout 93 diabetic pregnancies. Low levels of excretion (38% ) were common to all clinical categories of diabetes and were not influenced by either the duration or severity of the disease.The overalI perinatal loss was 13%; the incidence was 7% in patients with normal excretion values and 23% in those with low values. Six of the 8 deaths associated with low oestriol excretion occurred after birth and all were due to the respiratory distress syndrome. Low assays may warn of impending intra-uterine death, but intervention may not be possible. A normal excretion level should not, however, permit a complacent attitude.

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Section: %mentioning

confidence: 99%

Oestriol Excretion in the Pregnancy Complicated by Diabetes Mellitus

Evans

Taft

Rome

et al. 1972

Aust NZ J Obst Gynaeco

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“…Pour White, elle est onze fois plus fréquente que chez les parturientes non diabétiques (89). D'autre part la gestante diabétique est plus fré quemment victime d' infections surajoutées (44). En relation avec l'affection vasculaire, la pyélite gravidique n'est pas rare: selon Pederseu (62) l'infection des voies urinaires se retrouve dans 16 % des cas de grossesse diabétique.…”

Section: Répercussions Maternelles De La Grossesseunclassified

Endocrinopathies et grossesse

Mariéthod¹,

Chu-Chen²

1969

Gynecol Obstet Invest

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“…Although many factors may be responsible for these defects, recent evidence suggests that elevated levels of ketone bodies (specifically B-hydroxybutyrate [B-OHB]) may play a role (McLendon and Bottomy, 1960;Drury, 1966). Two separate studies using whole embryo culture techniques have shown that increased concentrations of DL-B-OHB are teratogenic to both mouse (Horton and Sadler, 1983) and rat (Lewis et al, 1983) embryos.…”

Section: Introductionmentioning

confidence: 96%

Mitochondrial alterations in embryos exposed to B‐hydroxybutyrate in whole embryo culture

Horton

Sadler

1985

Anat. Rec.

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The ketone body B-hydroxybutyrate (B-OHB) produces malformations and ultrastructural alterations in mitochondria of mouse embryos exposed for 24 hours to the compound in whole embryo culture. The present study was conducted to establish the time-course of the mitochondrial changes to determine whether the changes are reversible, and to relate these changes to the malformations produced by the compound. Since mitochondria also play a key role in the metabolism of ketone bodies, the capacity of the early somite embryo to metabolize B-OHB was investigated in an effort to link the morphological alterations in the mitochondria to a biochemical process. Early somite embryos were cultured 4, 8, or 24 hours in the presence of 32 mM DL-B-OHB and then cultured for an additional 24 hours in control serum. Finally, embryonic tissue during the teratogenic period was assessed for its capability to oxidize B-OHB using D-(3-14C)-B-OHB. The treated embryos showed progressive alterations in the mitochondria, beginning at 4 hours with a loss of matrix density and culminating at 24 hours with high-amplitude swelling, complete loss of matrix density, and disappearance of cristae. These alterations were reversible following removal of the embryos after 24 hours of exposure to B-OHB and culturing for an additional 24 hours in control serum. Metabolism studies demonstrated that the early somite embryo possesses a limited capacity to oxidatively metabolize B-OHB. The biochemical implications of these findings are discussed with respect to the possible role of ketone bodies in the mechanism of diabetes-induced congenital malformations.

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A critical analysis of the management of pregnancy in diabetic women

Cited by 12 publications

References 7 publications

Oestriol Excretion in the Pregnancy Complicated by Diabetes Mellitus

Oestriol Excretion in the Pregnancy Complicated by Diabetes Mellitus

Endocrinopathies et grossesse

Mitochondrial alterations in embryos exposed to B‐hydroxybutyrate in whole embryo culture

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