2010
DOI: 10.1097/hp.0b013e3181b8cffd
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A Critical Assessment of Biodosimetry Methods for Large-Scale Incidents

Abstract: Recognition is growing regarding the possibility that terrorism or large-scale accidents could result in potential radiation exposure of hundreds of thousands of people and that the present guidelines for evaluation after such an event are seriously deficient. Therefore, there is a great and urgent need for after-the-fact biodosimetric methods to estimate radiation dose. To accomplish this goal, the dose estimates must be at the individual level, timely, accurate, and plausibly obtained in large-scale disaster… Show more

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Cited by 63 publications
(58 citation statements)
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“…Dr Harold Swartzs group at Dartmouth Medical School (Hanover, New Hampshire, USA) has developed portable electron paramagnetic resonance (EPR) dosimeters that can measure low-LET radiation doses from teeth and finger nails 39,40 . The EPR signal is durable and it appears that the techniques can detect doses as low as 2 Gy 36,39,40 . Dr David Brenners group at Columbia University Medical Centre (New York, USA) has taken a very different approach, and is developing an automated device for measuring radiation-induced micronuclei and d-H2AX fluorescence in blood lymphocytes 41 .…”
Section: Progress On Biodosimetrymentioning
confidence: 99%
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“…Dr Harold Swartzs group at Dartmouth Medical School (Hanover, New Hampshire, USA) has developed portable electron paramagnetic resonance (EPR) dosimeters that can measure low-LET radiation doses from teeth and finger nails 39,40 . The EPR signal is durable and it appears that the techniques can detect doses as low as 2 Gy 36,39,40 . Dr David Brenners group at Columbia University Medical Centre (New York, USA) has taken a very different approach, and is developing an automated device for measuring radiation-induced micronuclei and d-H2AX fluorescence in blood lymphocytes 41 .…”
Section: Progress On Biodosimetrymentioning
confidence: 99%
“…If a mass-casualty incident occurs now, the only method for rapid (<12 h) radiation dose assessment would be time to emesis 37 . This is not actually very useful, since not all irradiated people (even those with large abdominal doses) vomit, and in many mass casualty scenarios, there will be other reasons that will cause people to vomit 36,38 . If more time was available, dose estimates could be made based on lymphocyte depletion kinetics, but that takes at least a day 36,37 .…”
Section: Progress On Biodosimetrymentioning
confidence: 99%
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