A critical examination of the use of the Freundlich isotherm in characterizing molecularly imprinted polymers (MIPs)

Rushton, Gregory T.; Karns, Chelsey L.; Shimizu, Ken D.

doi:10.1016/j.aca.2004.07.048

Cited by 111 publications

(59 citation statements)

References 9 publications

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“…The obtained data of adsorption isotherm equilibrium was analyzed using the Langmuir, Schatcard and Freundlich isotherm models [20][21][22]. The experimental data for various studied were fitted better with the rearranged Freundlich isotherm model over the Langmuir or Schatcard as the experimental data fall on a straight line when plotted in a logB vs logF format.…”

Section: Adsorption Isothermmentioning

confidence: 99%

“…The term a is a Freundlich parameter related to the binding affinity and the term m is the heterogeneity index [21] with values from zero to one, by one indicating homogeneity of the sites. This empirical equation is suitable for highly heterogeneous surfaces [20,21]. The Freundlich isotherm equation can be rearranged to a linear form: log B = m log F + log a Eq.…”

Section: Adsorption Isothermmentioning

confidence: 99%

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A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

Lagha¹

2011

TOCBMJ

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A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), from human urine. The synthesis of the MIP was performed in dimethylformamide with acrylamide as functional monomer, ethylene glycol dimethacrylate as the cross linker and ibuprofen template as the target drug. The performance of the synthesized MIP as solid phase extraction (SPE) packing to recognize and bind ibuprofen was evaluated against other structurally related NSAIDs such as naproxen and ketoprofen. Using a mixture of acetonitrile-water (1/9 v/v) as a solvent for ibuprofen the binding recovery at approximately 90% was obtained for developed MIP in optimized conditions. Batch rebinding capacity of ibuprofen was determined from the derived Freundlich isotherm and was found to be 1.45 mol g -1 . Furthermore, a higher selectivity of developed MIP for ibuprofen over structurally related analogues was observed. The synthesized MIP has enabled the direct percolation of humane urine and the easy elimination of endogenous compounds from it with simple aqueous washing of the MIP-SPE packing. HPLC analysis has confirmed the high extraction recovery (ca. 85 %) of ibuprofen from such urine samples with use of proposed MIP-SPE system.

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Section: Adsorption Isothermmentioning

confidence: 99%

Section: Adsorption Isothermmentioning

confidence: 99%

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

Lagha¹

2011

TOCBMJ

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“…The data given by this model can be explained, in most cases, taking into account that the Freundlich model is a generalization of the Langmuir model applied to a heterogeneous surface with an energy distribution corresponding to an exponential decrease. Although the Freundlich model predicts that there is an indefinite increase of the adsorbed solute increasing its concentration in solution, this empirical equation is suitable for highly heterogeneous surfaces [67][68][69][70] and often represents typical adsorption data over a restricted range of concentration. In spite that the Freundlich isotherm is suitable to describe the dependence between the coverage degree (θ) and the adsorption energy, it does not follow the fundamental thermodynamic basis since it does not reduce to Henry's law at lower concentrations nor predicts the monolayer saturation at higher concentrations.…”

Section: Isotherm Modelsmentioning

confidence: 99%

New Biosorbent Materials: Selectivity and Bioengineering Insights

Kyzas

Matis

2014

Processes

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Many researchers have studied the biosorption of different pollutants. However, a quite limited number of works focus on selectivity, which may be characterized as specific property for each biosorbent. Two main criteria need to be adopted for the selection and synthesis of modern biosorbents, such as their rebinding capacity and selectivity for only one target, molecule, ion, etc. Selective biosorption could be achieved using in synthesis an innovative technique termed molecular imprinting; the idea applied through specific polymers (Molecular Imprinted Polymers (MIPs)) was used in many fields, mainly analytical. In the present work, also isotherm and kinetic models were reviewed highlighting some crucial parameters, which possibly affect selectivity. A critical analysis of the biosorption insights for biosorbents, mostly selective, describes their characteristics, advantages and limitations, and discusses various bioengineering mechanisms involved.

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“…Term a is a Freundlich parameter related to the binding affinity and term m is the heterogeneity index with values from zero to one, one indicating homogeneity and zero indicating heterogeneity of the sites. This empirical equation is suitable for highly heterogeneous surfaces (12,13).…”

Section: Adsorption Isothermsmentioning

confidence: 99%

Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues

Lahsini¹,

Louhaichi²,

Adhoum³

et al. 2013

Acta Pharmaceutica

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The performance of a molecularly imprinted polymer (MIP) as selective packing material for solid-phase extraction (SPE) of residual glibenclamide in an industrial process was investigated. MIP was prepared using 4-vinylpyridine as monomer, ethylenedimethacrylate as cross linker, 2,2’-azobis-2-methylpropionitrile as initiator and dimethyl formamide as porogen. Use of acetonitrile as a rebinding solvent allows good recognition of the glibenclamide template. It was found that this polymer can be used for determination of trace levels of glibenclamide with a recovery percentage that could reach 87.1 %. Furthermore, the synthesized MIP showed higher selectivity towards glibenclamide than other compounds such as glimepiride and metformine. The synthesized MIP enabled direct determination of the target contaminant after an enrichment step that allowed quantification of glibenclamide at a concentration as low as 0.016 mg L-1. Combination of high performance liquid chromatography with MIP-SPE could be successfully used for quality control of pharmaceuticals during the cleaning process in the production of dry drug forms.

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A critical examination of the use of the Freundlich isotherm in characterizing molecularly imprinted polymers (MIPs)

Cited by 111 publications

References 9 publications

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

New Biosorbent Materials: Selectivity and Bioengineering Insights

Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues

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