A Critical Overview of the Chemistry of Copper-Dependent Low Density Lipoprotein Oxidation: Roles of Lipid Hydroperoxides, α-Tocopherol, Thiols, and Ceruloplasmin

Burkitt, Mark J.

doi:10.1006/abbi.2001.2509

Cited by 255 publications

(170 citation statements)

References 144 publications

Supporting

Mentioning

165

Contrasting

Unclassified

Order By: Relevance

“…The mechanisms by which Cu 2+ ions initiate and propagate the oxidation of LDL remain a matter of contention [12]. Both α-tocopheroxyl (α-Toc-O • ) and hydroxyl ( • OH) radicals have been suggested to be responsible for the initiation of polyunsaturated fatty acid oxidation within LDL.…”

Section: Discussionmentioning

confidence: 99%

“…Since this reaction is extremely slow (k 10 ≈ 0.1 ± 0.05 M -1 s -1 at 37 o C), it has been suggested that the much more reactive • OH radical, generated via the sequential reduction of molecular oxygen by Cu + , is the species responsible for the initiation of LDL oxidation (Reactions 11 -15, showing both the initial one-and two-electron oxygen reduction pathways) [12,74]. …”

Section: Discussionmentioning

confidence: 99%

“…LDL oxidation by cells in vitro appears to be dependent usually on the presence of iron or copper ions in a redox-active form, which are believed to catalyse the free-radical reactions responsible for LDL oxidation [3][4][5][9][10][11]. Metal ions can also oxidise LDL directly when incubated in cell-free medium [3,4,9,12].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mechanism of the antioxidant to pro-oxidant switch in the behavior of dehydroascorbate during LDL oxidation by copper(II) ions

Horsley

Burkitt

Jones

et al. 2007

Archives of Biochemistry and Biophysics

Self Cite

View full text Add to dashboard Cite

Subject area: Systems biochemistryAbbreviations: BCDS, bathocuproine disulphonic acid; DMPO,5, EPR, electron paramagnetic resonance; 13-HPODE, 13(S)-hydroperoxyoctadeca-9Z,11E-dienoic acid 2 ABSTRACTOxidised low density lipoprotein (LDL) may be involved in the pathogenesis of atherosclerosis.We have therefore investigated the mechanisms underlying the antioxidant/pro-oxidant behavior of dehydroascorbate, the oxidation product of ascorbic acid, toward LDL incubated with Cu 2+ ions. By monitoring lipid peroxidation through the formation of conjugated dienes and lipid hydroperoxides, we show that the pro-oxidant activity of dehydroascorbate is critically dependent on the presence of lipid hydroperoxides, which accumulate during the early stages of oxidation.Using electron paramagnetic resonance spectroscopy, we show that dehydroascorbate amplifies the generation of alkoxyl radicals during the interaction of copper ions with the model alkyl hydroperoxide, tert-butylhydroperoxide. Under continuous-flow conditions, a prominent doublet signal was detected, which we attribute to both the erythroascorbate and ascorbate free radicals.On this basis, we propose that the pro-oxidant activity of dehydroascorbate toward LDL is due to its known spontaneous interconversion to erythroascorbate and ascorbate, which reduce Cu 2+ to Cu + and thereby promote the decomposition of lipid hydroperoxides. Various mechanisms, including copper chelation and Cu + oxidation, are suggested to underlie the antioxidant behavior of dehydroascorbate in LDL that is essentially free of lipid hydroperoxides.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Mechanism of the antioxidant to pro-oxidant switch in the behavior of dehydroascorbate during LDL oxidation by copper(II) ions

Horsley

Burkitt

Jones

et al. 2007

Archives of Biochemistry and Biophysics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Excess vitamin E antagonizes vitamin K, reduces platelet aggregation, promoting anti-coagulant activity [41], it also interferes with generation of beneficial ROS flood used for killing of the infective phagocytosis agents engulfed by granulocytes [53][54][55]. Vitamin E in high doses becomes pro oxidant [56,57].…”

Section: Excess Use Of Vitamins Leads To Interactions and Reverses Thmentioning

confidence: 99%

The Concept of Cyclical Nutritional Therapy for Hair Growth which can be Applied for Wellness

Rajput¹

2017

J Nutr Food Sci

View full text Add to dashboard Cite

Hair growth can be achieved by fighting hair loss with medications or by strengthening the hair roots with nutrients. Caution as excess vitamin A, vitamin E, omega 3 cause hair loss instead of hair growth. Supplements are considered harmless and consumed without thinking of interactions or overdose. Therapeutic doses of vitamins to treat disease are high, however preventive or prophylactic dose for wellness are low. Antioxidants improve health by neutralizing Reactive oxygen species, but ROS have important role in infection control and phagocytosis. Overuse of antioxidants interferes with protective mechanisms. High doses of one nutrient affect the absorption and efficiency of others. Administered together, vitamin C can destroy vitamin B12. Iron and calcium reduce the absorption of one another. High vitamin C, increases sodium & reduces potassium levels. Nutrients are also synergistic. Vitamin E regenerates Beta carotene. Vitamin C regenerates vitamin E. Toxic effects of Beta carotene break down products are reduced by alpha tocopherol, N acetyl cysteine and vitamin C. Single deficiency causes multiple inefficiencies. Inappropriate combinations and nutrient overdose are easily possible with rising use of multivitamins and fortified foods. Nutrient deficiencies are compensated by autophagy and also prevail as subclinical deficiencies making them difficult to detect on laboratory tests. To utilize nutrients without interaction and overdose we have proposed the use of different synergistic nutrients on different days of the week, repeating in a three day cycle. The concept was initiated for achieving consistent hair growth as published earlier. It can be applied to a set of nutrients identified for various other indications like geriatrics, pediatrics, growing teens, athletes, body builders, women's health, cardiac patients, diabetics, athletes, bariatric surgery etc. ensuring low dose, low cost, and optimum benefit nutrient program allowing the body to assimilate and utilize each nutrient, without wastage or overdose.

show abstract

“…Copper, despite a small demand by turkeys amounting to circa 2-4 mg per kg −1 of feed, conditions the proper course of a number of processes and functions, that is, forming collagen cross linkages, skeleton mineralization, haem biosynthesis, oxidative phosphorylation, glucose and cholesterol metabolism, immunological functions, central nervous system functioning and a lot of others (Burkitt 2001;Samanta et al 2011;Gaetke et al 2014). Copper is often added to poultry feeds in increased quantities for preventive purposes because it stimulates the weight gain (Pesti & Bakalli 1996).…”

Section: Introductionmentioning

confidence: 99%

Fattening turkeys with the addition of lactic acid and copper

Kuna-Broniowska

Makarska²,

Nowakowicz-Dębek

et al. 2016

Journal of Applied Animal Research

View full text Add to dashboard Cite

The paper presents results of research on the effects of different doses of copper in the form of CuSO 4 ·5H 2 O and Cu chelate and lysine (1:2), also with 0.4% lactic acid in drinking water on weight gain of turkeys. The study sample consists of 20 experimental groups of 120 birds each. The addition of lactic acid to the feed (excluding copper) contributed slightly to the reduction of the weight gain of turkeys. In contrast, a significant decrease in body weight gain of turkeys was observed, using lactic acid along with inorganic form of copper. Turkeys fed with the feed containing only organic form of copper at a dose of 20 mg reached the greatest weight gain. Lactic acid and different doses and forms of copper significantly differentiate the body weight gain of turkeys. The combination of the lactic acid and copper added resulted in lower weight gains of birds; it was only the administration of the 50 mg copper dose in organic form that increased the weight gain to the level comparable to the weight gains obtained for birds fed without the lactic acid addition. The use of feed supplements requires the selection of an appropriate dose to the form of copper. ARTICLE HISTORY

show abstract

A Critical Overview of the Chemistry of Copper-Dependent Low Density Lipoprotein Oxidation: Roles of Lipid Hydroperoxides, α-Tocopherol, Thiols, and Ceruloplasmin

Cited by 255 publications

References 144 publications

Mechanism of the antioxidant to pro-oxidant switch in the behavior of dehydroascorbate during LDL oxidation by copper(II) ions

Mechanism of the antioxidant to pro-oxidant switch in the behavior of dehydroascorbate during LDL oxidation by copper(II) ions

The Concept of Cyclical Nutritional Therapy for Hair Growth which can be Applied for Wellness

Fattening turkeys with the addition of lactic acid and copper

Contact Info

Product

Resources

About