A critical reappraisal of the current data on drug-induced linear immunoglobulin A bullous dermatosis: A real and separate nosological entity?

Fortuna, Giulio; Salas‐Alanís, Julio C.; Eugenio, Guidetti; Marinkovich, M. Peter

doi:10.1016/j.jaad.2011.09.018

Cited by 81 publications

(104 citation statements)

References 51 publications

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“…The recent review of the previously reported cases of drug-induced LABD showed that the onset of cutaneous manifestations upon administration of the suspected drug ranged from 1 to 780 days. 2 On the other hand, similarly to our patient, there was a case report of drug-induced type of the disease which occurred two weeks after discontinuance of the treatment with the offending drug. 6 The mechanism of drug-induced LABD remains unclear.…”

Section: Discussionsupporting

confidence: 82%

“…Some cases were confirmed with the dechallenge-rechallenge procedure. 2 Our patient denied taking any another drugs. For ethical reasons, we did not rechallenge the patient.…”

Section: Figurementioning

confidence: 78%

“…Thus it is likely that an amplification of the immunological signal occurred in some cases of drug-induced LABD, resulting in a self-maintaining immune response. 2 Usually first exposure to the drug induces primary asymptomatic autoimmune response. However some authors have suggested that clinical conditions such as infections (for example upper respiratory tract infections) may act as were on the erythematous and oedematous background.…”

Section: Discussionmentioning

confidence: 99%

“…2 In contrast to idiopathic LABD, long-term therapy is not necessary in drug-induced variant. 1,2 Dapsone is considered to be the first-line therapy. Its efficiency has been proven in monotherapy or in combination with other drugs, such as: corticosteroids, nicotinamide and antibiotics.…”

Section: Figurementioning

confidence: 99%

“…However, other antibiotics, such as trimethoprim-sulfamethoxazole, ampicillin/sulbactam and amoxicillin-clavulanic acid have also been reported. 2 As far as we know, cefuroxime has been reported only once in a case of LABD. 3 Herein, we described a case of drug-induced LABD three weeks after cefuroxime axetil termination.…”

Section: Introductionmentioning

confidence: 96%

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Drug-induced linear IgA bullous dermatosis after discontinuation of cefuroxime axetil treatment

Pastuszczak¹,

Lipko-Godlewska²,

Jaworek³

et al. 2012

J Dermatol Case Rep

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Background: Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is a rare autoimmune blistering disorder. The disease may be either idiopathic or druginduced. Over the past 30 years, approximately one hundred LABD cases have been described as induced by a wide range of drugs, chiefly antibiotics. Main observations:We report the case of 37-year-old woman who developed pruritic bullous lesions spread all over the body three weeks after her last dose of cefuroxime axetil. Antibiotic therapy was started due to rhino-sinusitis. Conclusions:In most reported cases of drug-induced LABD, skin lesions occur within the time of drug administration. However, the onset of disease may be even after discontinuation of treatment. It seems that in such cases, other clinical conditions (like infection) act, as cofactors of immunologic response. (J Dermatol Case Rep.

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Section: Discussionsupporting

confidence: 82%

“…Some cases were confirmed with the dechallenge-rechallenge procedure. 2 Our patient denied taking any another drugs. For ethical reasons, we did not rechallenge the patient.…”

Section: Figurementioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%