A critical review and evaluation of bioproduction of organic chemicals

Leeper, S.A.; Andrews, Graham F.

doi:10.1007/bf02922629

Cited by 17 publications

(4 citation statements)

References 16 publications

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“…Such factors include substrate cost (8,9) and the ability to produce biodegradable polymers from inexpensive and renewable carbon sources, such as xylose and lactose (6). Recent estimates indicate that 435 million dry tons of agricultural and forestry residues containing xylose is produced per year (15). Lactose is generated in large volumes from cheese whey.…”

mentioning

confidence: 99%

Microbial Production of Poly-β-Hydroxybutyric Acid from d -Xylose and Lactose by Pseudomonas cepacia

Young

Kastner

May

1994

Appl Environ Microbiol

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Poly-f-hydroxybutyric acid (PHB) was produced from xylose and lactose by using Pseudomonas cepacia. Approximately 50%o PHB (grams of PHB total/grams of biomass total) was produced. With a laser-based fluorescent probe, 13-galactosidase activity was shown to be induced in P. cepacia cells grown on lactose but not in those grown on glucose or xylose. P. cepacia has the potential to produce biodegradable thermoplastics from hemicellulosic hydrolysates and cheese whey.

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mentioning

confidence: 99%

Microbial Production of Poly-β-Hydroxybutyric Acid from d -Xylose and Lactose by Pseudomonas cepacia

Young

Kastner

May

1994

Appl Environ Microbiol

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“…4,5 Th e focus of most prior analyses has been coproduction of fuels with chemicals and other non-fuel. 6,7 While chemicals' coproduction could potentially improve process economics, fuels must be the primary product if biomass refi ning is to make more than a small contribution to sustainability and security challenges facing society.…”

Section: Introductionmentioning

confidence: 99%

Projected mature technology scenarios for conversion of cellulosic biomass to ethanol with coproduction thermochemical fuels, power, and/or animal feed protein

Laser

Jin²,

Jayawardhana³

et al. 2009

Biofuels Bioprod Bioref

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Seven process designs for producing ethanol and several coproducts from switchgrass are evaluated:four involving combinations of ethanol, thermochemical fuels (including Fischer-Tropsch liquids, hydrogen, and methane) and/or power, and three coproducing animal feed protein. Material and energy balances -resulting from detailed Aspen Plus models -are reported and used to estimate processing costs and perform discounted cash fl ow analysis to assess plant profi tability. In these mature technology designs, fossil fuel displacement is decidedly positive and production costs competitive with gasoline.

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“…bio-based chemicals having similar functionality as petrochemicals, without duplicating the exact molecular structure) (Lipinsky, 1981). The economies of scale and the cost reductions created by operating a highly optimized (from numerous years of operation) petrochemical process make it very difficult for new bio-based processes to compete as direct substitutes (Cherubini and Strømman, 2011;Leeper and Andrews, 1991;Siddiqui et al, 2013). For these reasons, commercial success, (e.g.…”

Section: Introductionmentioning

confidence: 99%

A roadmap for the synthesis of separation networks for the recovery of bio-based chemicals: Matching biological and process feasibility

Yenkie

Clark

et al. 2016

Biotechnology Advances

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Microbial conversion of renewable feedstocks to high-value chemicals is an attractive alternative to current petrochemical processes because it offers the potential to reduce net CO emissions and integrate with bioremediation objectives. Microbes have been genetically engineered to produce a growing number of high-value chemicals in sufficient titer, rate, and yield from renewable feedstocks. However, high-yield bioconversion is only one aspect of an economically viable process. Separation of biologically synthesized chemicals from process streams is a major challenge that can contribute to >70% of the total production costs. Thus, process feasibility is dependent upon the efficient selection of separation technologies. This selection is dependent on upstream processing or biological parameters, such as microbial species, product titer and yield, and localization. Our goal is to present a roadmap for selection of appropriate technologies and generation of separation schemes for efficient recovery of bio-based chemicals by utilizing information from upstream processing, separation science and commercial requirements. To achieve this, we use a separation system comprising of three stages: (I) cell and product isolation, (II) product concentration, and (III) product purification and refinement. In each stage, we review the technology alternatives available for different tasks in terms of separation principles, important operating conditions, performance parameters, advantages and disadvantages. We generate separation schemes based on product localization and its solubility in water, the two most distinguishing properties. Subsequently, we present ideas for simplification of these schemes based on additional properties, such as physical state, density, volatility, and intended use. This simplification selectively narrows down the technology options and can be used for systematic process synthesis and optimal recovery of bio-based chemicals.

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A critical review and evaluation of bioproduction of organic chemicals

Cited by 17 publications

References 16 publications

Microbial Production of Poly-β-Hydroxybutyric Acid from d -Xylose and Lactose by Pseudomonas cepacia

Microbial Production of Poly-β-Hydroxybutyric Acid from d -Xylose and Lactose by Pseudomonas cepacia

Projected mature technology scenarios for conversion of cellulosic biomass to ethanol with coproduction thermochemical fuels, power, and/or animal feed protein

A roadmap for the synthesis of separation networks for the recovery of bio-based chemicals: Matching biological and process feasibility

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